The Medical College of Wisconsin (MCW) has received a four year, $1.5 million grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to study the role of a specific microRNA in the development of hypertension and associated kidney injury.
Mingyu Liang, M.B., Ph.D., professor of physiology, is the primary investigator of the grant. Other investigators involved include Alison Kriegel, PhD, assistant professor of physiology, Pengyuan Liu, Ph.D., associate professor of physiology, Kristie Usa, laboratory supervisor, and Yong Liu, Ph.D., research scientist.
According to the Centers for Disease Control, one third of adults in the United States—67 million—have high blood pressure, also known as hypertension. In nearly half that population, the condition is not treated or controlled. Hypertension is a major risk factor for a variety of severe diseases, including end-stage kidney disease.
In this research project, Dr. Liang will investigate the role of a specific microRNA called miR-29 in the development of hypertension and associated kidney injury. MicroRNA’s are regulatory mechanisms in the body that play critical roles in a wide range of disease processes. Dr. Liang’s previous work showed an insufficiency of miR-29 could cause renal injury. This study will test if miR-29 insufficiency contributes to hypertension and examine the molecular mechanisms at work.
Ultimately, this project could reveal new mechanisms involved in hypertension, and may lead to new therapeutic targets.
This project is funded by NIH grant 5P01HL082798-09.
Your link to the biggest stories in the suburbs delivered Thursday mornings.
Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter Get the Newsletter!
- Holiday Folk Fair International Offers Advance Ticket Purchase Opportunities
- Milwaukee/NARI Offers November 5 Panel Discussion on Refreshing Mudroom and Laundry Room
- Paul Pennoyer Joins Bartelt as a Lead Carpenter
- Help Tarte make Sweet Dreams come true this season!
- Tosa West Alumni Publishes Book
- VMP Manor Park Pumpkin Smash
- Volunteer! It's the "nice" of life!
- The role of the church in HIV prevention
- Wauwatosa Health Department Flu Clinics
- Chicago Bus Trip Planned