MCW to design national clinical trial for treatment of a lung disease in primary immunodeficiency
The Medical College of Wisconsin (MCW) and the Children’s Hospital of Wisconsin Research Institute have received a one-year, $280,000 grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to design a multi-center clinical trial.
John Routes, M.D., professor and chief of asthma, allergy, and immunology at MCW and medical director of asthma, allergy and clinical immunology at Children’s Hospital of Wisconsin, is the primary investigator on the project.
Common variable immune deficiency (CVID) is a fairly rare disorder (1 in 25,000) that impairs the immune system, making people highly susceptible to infections. Ten to 15 percent of patients with CVID develop a complication called granulomatous/lymphocytic interstitial lung disease (GLILD), which is a progressive disease that restricts the ability to breathe, and is a significant cause of death in immune-compromised patients who develop GLILD.
There is no established standard of care for treating GLILD. However, Dr. Routes’ research team recently found an immunosuppressive therapy using two FDA-approved drugs improved the lung function in a select group of patients with GLILD.
With this grant funding, Dr. Routes will design a multicenter, placebo controlled trial for patients with GLILD. Designing a trial includes recruiting a sufficient number of investigators and centers, developing a leadership structure, establishing clinical and scientific cores, creating regulatory documents and manuals of procedures, and developing a database for data collection.
This project is supported by NIH grant R34 AI106570-01A1.
Your link to the biggest stories in the suburbs delivered Thursday mornings.
Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter Get the Newsletter!
- Summer School Program Comes Home to the Milwaukee Irish Fest Center
- Greater Brookfield Chamber of Commerce presents “Violence in the Workplace” workshop
- Ten Wisconsin High School Seniors Win BBB Foundation’s “Student of Integrity” Scholarship
- Early Registration for Walk, Run, Wag for MADACC Ends May 1
- Milwaukee/NARI Remodeling Professionals Recognized on National Level
- MCW researcher to investigate diabetic heart susceptibility to cardiac sensitivity
- Go Green, Gold and Pink for Breast Cancer Awareness
- Milwaukee/NARI Says April Showers Don’t Have to Bring Foundation Leaks
- Parade Applications Now Available
- Greater Brookfield Chamber of Commerce presents former Navy SEAL, Jeff Boss, leadership coach specializing in adaptability