NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
70°
H 81° L 57°
Clear | 5MPH

Researchers to explore new treatments for pancreatic cancer

July 18, 2014

The Medical College of Wisconsin (MCW) has received a five-year, $2.6 million grant from the National Institutes of Health’s National Cancer Institute to study new therapeutic approaches to treat pancreatic cancer.

Michael Dwinell, Ph.D., associate professor of microbiology and molecular genetics at MCW; and Balaraman Kalyanaraman, Ph.D., Harry R. & Angeline E. Quadracci Professor in Parkinson’s Research and the professor and chairman of biophysics at MCW; are co-principal investigators of the grant.

About 46,000 people in the United States will be diagnosed with pancreatic cancer this year. Pancreatic ductal carcinoma, which comprises 90 percent of those cases, is a highly aggressive cancer. A combination of radiation, chemotherapy and surgical options can extend survival time, but there is no consistently successful treatment.

Emerging research in cancer therapy is focused on exploiting the differences between cancer cell metabolism and normal cell metabolism. Metastasis of cancer, or the proliferation of cancerous cells, is the mechanism by which cancer spreads through the body, eventually leading to the patient’s death.

In this project, the researchers will work to develop new methods of slowing or halting the metastasis of cancer cells by investigating a combination of energy metabolism inhibitors with relatively nontoxic mitochondria- targeted drugs. The results will advance researchers’ understanding of the roles of metabolism and energy in pancreatic cancer malignancy. Further, it could lead to the design and testing of new drugs that would halt the energy production of malignant cells, and ultimately lead to new therapies to treat pancreatic cancer.

Other MCW investigators involved in the research include Susan Tsai, M.D., M.H.S., assistant professor of surgery (co-investigator); Douglas Evans, M.D., Donald C. Ausman Family Foundation Professor chairman of surgery at MCW (consultant); Alexander Craig Mackinnon, M.D., Ph.D., assistant professor of pathology at MCW (consultant). Other MCW personnel include Gang Cheng, Ph.D., research scientist I in biophysics; Jacek Zielonka, Ph.D., research scientist II in biophysics; Ishan Roy, research assistant in the Medical Student Training Program; Donna McAllister, research associate I in biophysics and microbiology and molecular genetics, and Kris Dilkey, laboratory technician III in microbiology and molecular genetics.

This project will also be conducted with the National Cancer Institute intramural researchers Murali Krishna Cherukuri, Ph.D., head, biophysical spectroscopy section, Radiation Biology Branch, NCI; and Peter Choyke, M.D., F.A.C.R., chief, molecular imaging program, Center for Cancer Research, NCI, who will consult on the project.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Get interesting prep football tidbits and insights with 'First and Short' blog 8/28

» Hundreds of Tosa residents experienced short power outage Aug. 27 8/28

» Updated weekly rankings of area prep football teams and players 8/27

» Wauwatosa Village valet service tentatively halted on Sundays 8/27

» Wauwatosa East girls cross-country team looking for good things 8/26

» Wauwatosa West returnees should help girls cross-country team 8/26

» Wauwatosa East tennis team has nine returning players 8/26

» Wauwatosa West girls volleyball team has holes to fill 8/26

» Wauwatosa girls golf team fourth at first GMC mini-meet 8/26

» Potter to lead Wauwatosa East boys cross-country team 8/26

» Initial Reaction Podcast: What stood out on the first week of high-school football? 8/25

» Suspected pipe bomb draws neighborhood attention in Wauwatosa Updated:  8/24

» Carey, defense spark New Berlin Eisenhower win 8/24

» Wauwatosa School District mobile app now available for download 8/24

» Bomb squad blasts suspicious canister found at East Tosa gas station Updated:  8/23

» Police detonate suspicious object near Wauwatosa gas station 8/23

» Defense takes the spotlight in 'Battle of Tosa' 8/22

» Defense shines as West beat East, 17-0 8/21

» Bryant & Stratton College debuts health care labs in Wauwatosa to aid in field experiences 8/21

» Tosa Street Style event takes place Aug. 21 - 22 8/20

» Public invited to Monarch butterfly migration celebration 8/20

» The 2015 Suburban Milwaukee Prep Football Guide 8/19

» Get to know: Wauwatosa East Red Raiders 8/19

» Weather moves Wauwatosa City Softball title to Tuesday at Hart Park 8/19

» Wauwatosa West girls tennis team seeks third straight triple crown 8/19

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

Advertisement

Local Business Directory

CONNECT