NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
81°
H 82° L 63°
Partly Cloudy | 15MPH

Researchers to explore new treatments for pancreatic cancer

July 18, 2014

The Medical College of Wisconsin (MCW) has received a five-year, $2.6 million grant from the National Institutes of Health’s National Cancer Institute to study new therapeutic approaches to treat pancreatic cancer.

Michael Dwinell, Ph.D., associate professor of microbiology and molecular genetics at MCW; and Balaraman Kalyanaraman, Ph.D., Harry R. & Angeline E. Quadracci Professor in Parkinson’s Research and the professor and chairman of biophysics at MCW; are co-principal investigators of the grant.

About 46,000 people in the United States will be diagnosed with pancreatic cancer this year. Pancreatic ductal carcinoma, which comprises 90 percent of those cases, is a highly aggressive cancer. A combination of radiation, chemotherapy and surgical options can extend survival time, but there is no consistently successful treatment.

Emerging research in cancer therapy is focused on exploiting the differences between cancer cell metabolism and normal cell metabolism. Metastasis of cancer, or the proliferation of cancerous cells, is the mechanism by which cancer spreads through the body, eventually leading to the patient’s death.

In this project, the researchers will work to develop new methods of slowing or halting the metastasis of cancer cells by investigating a combination of energy metabolism inhibitors with relatively nontoxic mitochondria- targeted drugs. The results will advance researchers’ understanding of the roles of metabolism and energy in pancreatic cancer malignancy. Further, it could lead to the design and testing of new drugs that would halt the energy production of malignant cells, and ultimately lead to new therapies to treat pancreatic cancer.

Other MCW investigators involved in the research include Susan Tsai, M.D., M.H.S., assistant professor of surgery (co-investigator); Douglas Evans, M.D., Donald C. Ausman Family Foundation Professor chairman of surgery at MCW (consultant); Alexander Craig Mackinnon, M.D., Ph.D., assistant professor of pathology at MCW (consultant). Other MCW personnel include Gang Cheng, Ph.D., research scientist I in biophysics; Jacek Zielonka, Ph.D., research scientist II in biophysics; Ishan Roy, research assistant in the Medical Student Training Program; Donna McAllister, research associate I in biophysics and microbiology and molecular genetics, and Kris Dilkey, laboratory technician III in microbiology and molecular genetics.

This project will also be conducted with the National Cancer Institute intramural researchers Murali Krishna Cherukuri, Ph.D., head, biophysical spectroscopy section, Radiation Biology Branch, NCI; and Peter Choyke, M.D., F.A.C.R., chief, molecular imaging program, Center for Cancer Research, NCI, who will consult on the project.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» J. Crew Mercantile to open store at The Mayfair Collection 7/30

» Wednesday house fire causes $100,000 in damage to Tosa home 7/30

» A Wauwatosa artist's unique work will be on display at the Firefly Art Fair 7/29

» Wauwatosa Meetings: July 30 7/29

» Wauwatosa West's inexperience affects season in close losses 7/29

» Six Wauwatosa East baseball players earn GMC honors on some level 7/29

» Land O'Lakes game brings back good memories 7/29

» Jr. Trojans set baseball tryouts for U9-U14 teams 7/28

» Tosa's Night Out set for Aug. 4 at Hart Park 7/28

» 'Milwaukee lion' spotted in Glendale Updated:  7/28

» Mayfair holds back-to-school style event 7/28

» Medical College of Wisconsin construction begins Aug. 3 7/24

» Therapy program's art gallery opening is this weekend 7/22

» The Suburban 16 Power Rankings: Watt, Niebrugge, and others on the next level 7/22

» The Landing at Hoyt Park has become destination for local musicians 7/22

» Wauwatosa West loses pitchers' duel to Pius in regional semifinal 7/22

» Where did the summer go? 7/22

» Sports Notes: July 23, 2015 7/22

» Pewaukee's fast start ends Wauwatosa East baseball team's season 7/22

» Initial Reaction Podcast: A dumb-sports-fan's guide to the Bucks arena financing situation 7/21

» Upcoming Wauwatosa meeting to discuss housing for people with disabilities 7/21

» Milwaukee Co. Zoo gains two snow leopards 7/20

» Meijer announces $25,000 donation to Wauwatosa Library 7/20

» Man shot, killed by Wauwatosa police was brandishing sword Updated:  7/18

» Wauwatosa early learning program to begin this fall 7/17

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

2015 Writing Contest

 

(Click image for details)

Advertisement

Local Business Directory

CONNECT