NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
64°
H 75° L 64°
Clear | 13MPH

Researchers to explore new treatments for pancreatic cancer

July 18, 2014

The Medical College of Wisconsin (MCW) has received a five-year, $2.6 million grant from the National Institutes of Health’s National Cancer Institute to study new therapeutic approaches to treat pancreatic cancer.

Michael Dwinell, Ph.D., associate professor of microbiology and molecular genetics at MCW; and Balaraman Kalyanaraman, Ph.D., Harry R. & Angeline E. Quadracci Professor in Parkinson’s Research and the professor and chairman of biophysics at MCW; are co-principal investigators of the grant.

About 46,000 people in the United States will be diagnosed with pancreatic cancer this year. Pancreatic ductal carcinoma, which comprises 90 percent of those cases, is a highly aggressive cancer. A combination of radiation, chemotherapy and surgical options can extend survival time, but there is no consistently successful treatment.

Emerging research in cancer therapy is focused on exploiting the differences between cancer cell metabolism and normal cell metabolism. Metastasis of cancer, or the proliferation of cancerous cells, is the mechanism by which cancer spreads through the body, eventually leading to the patient’s death.

In this project, the researchers will work to develop new methods of slowing or halting the metastasis of cancer cells by investigating a combination of energy metabolism inhibitors with relatively nontoxic mitochondria- targeted drugs. The results will advance researchers’ understanding of the roles of metabolism and energy in pancreatic cancer malignancy. Further, it could lead to the design and testing of new drugs that would halt the energy production of malignant cells, and ultimately lead to new therapies to treat pancreatic cancer.

Other MCW investigators involved in the research include Susan Tsai, M.D., M.H.S., assistant professor of surgery (co-investigator); Douglas Evans, M.D., Donald C. Ausman Family Foundation Professor chairman of surgery at MCW (consultant); Alexander Craig Mackinnon, M.D., Ph.D., assistant professor of pathology at MCW (consultant). Other MCW personnel include Gang Cheng, Ph.D., research scientist I in biophysics; Jacek Zielonka, Ph.D., research scientist II in biophysics; Ishan Roy, research assistant in the Medical Student Training Program; Donna McAllister, research associate I in biophysics and microbiology and molecular genetics, and Kris Dilkey, laboratory technician III in microbiology and molecular genetics.

This project will also be conducted with the National Cancer Institute intramural researchers Murali Krishna Cherukuri, Ph.D., head, biophysical spectroscopy section, Radiation Biology Branch, NCI; and Peter Choyke, M.D., F.A.C.R., chief, molecular imaging program, Center for Cancer Research, NCI, who will consult on the project.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Run Tosa Run raises $3K for Ronald McDonald House 5/26

» Longfellow hosting Wauwatosa's Memorial Day ceremony Monday 5/21

» Choice school, dry cleaning issues held for more discussion in Wauwatosa 5/20

» Parents rally after lawmakers expand vouchers 5/20

» Wauwatosa approves conceptual design for pocket park on North Avenue Updated:  5/20

» Wauwatosa hotel site sells for $925,000 5/20

» Tosa Tonight releases lineup for summer concert series 5/19

» Wauwatosa School Board approves raises for teachers, administrators and staff 5/19

» Wauwatosa Avenue lane to close over Memorial Day weekend 5/18

» Residents invited to help redesign streets, parks in Wauwatosa Village 5/15

» Wauwatosa alderman pulls proposal to shrink common council 5/15

» Police arrest teens for prowling after foot chase through Wauwatosa Updated:  5/14

» Initial Reaction Podcast: Massive overhaul of area conferences could be afoot 5/13

» Beer garden at Hoyt Park in Tosa reopens Wednesday, may go indoors too 5/12

» Winter's not through with us yet 5/12

» Wauwatosa mayor named to MMSD governing commission 5/11

» Police say motorcyclist riding without helmet injured in Wauwatosa collision 5/7

» Ex-Wauwatosa school board vice president 'disheartened by political dissonance' in community Updated:  5/6

» Wauwatosa celebrating Bike to School Day Wednesday 5/5

» Wauwatosa alderman proposes cutting four seats on Common Council 5/4

» East kickers blank Tosa West, 2-0 5/2

» Investigation: Family behind collapsed Falls building has a history of neglecting properties Updated:  5/1

» Wauwatosa's Lady in Red reopens as Nikki's Boutique after remodel 4/30

» Exactly 175 years ago, Wauwatosa became a town 4/30

» Tosa Recreation Dept. to hold textile recycling event 4/29

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

2015 Writing Contest

 

(Click image for details)

Local Business Directory

CONNECT