NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
68°
H 68° L 41°
Cloudy | 5MPH

Researchers to explore new treatments for pancreatic cancer

July 18, 2014

The Medical College of Wisconsin (MCW) has received a five-year, $2.6 million grant from the National Institutes of Health’s National Cancer Institute to study new therapeutic approaches to treat pancreatic cancer.

Michael Dwinell, Ph.D., associate professor of microbiology and molecular genetics at MCW; and Balaraman Kalyanaraman, Ph.D., Harry R. & Angeline E. Quadracci Professor in Parkinson’s Research and the professor and chairman of biophysics at MCW; are co-principal investigators of the grant.

About 46,000 people in the United States will be diagnosed with pancreatic cancer this year. Pancreatic ductal carcinoma, which comprises 90 percent of those cases, is a highly aggressive cancer. A combination of radiation, chemotherapy and surgical options can extend survival time, but there is no consistently successful treatment.

Emerging research in cancer therapy is focused on exploiting the differences between cancer cell metabolism and normal cell metabolism. Metastasis of cancer, or the proliferation of cancerous cells, is the mechanism by which cancer spreads through the body, eventually leading to the patient’s death.

In this project, the researchers will work to develop new methods of slowing or halting the metastasis of cancer cells by investigating a combination of energy metabolism inhibitors with relatively nontoxic mitochondria- targeted drugs. The results will advance researchers’ understanding of the roles of metabolism and energy in pancreatic cancer malignancy. Further, it could lead to the design and testing of new drugs that would halt the energy production of malignant cells, and ultimately lead to new therapies to treat pancreatic cancer.

Other MCW investigators involved in the research include Susan Tsai, M.D., M.H.S., assistant professor of surgery (co-investigator); Douglas Evans, M.D., Donald C. Ausman Family Foundation Professor chairman of surgery at MCW (consultant); Alexander Craig Mackinnon, M.D., Ph.D., assistant professor of pathology at MCW (consultant). Other MCW personnel include Gang Cheng, Ph.D., research scientist I in biophysics; Jacek Zielonka, Ph.D., research scientist II in biophysics; Ishan Roy, research assistant in the Medical Student Training Program; Donna McAllister, research associate I in biophysics and microbiology and molecular genetics, and Kris Dilkey, laboratory technician III in microbiology and molecular genetics.

This project will also be conducted with the National Cancer Institute intramural researchers Murali Krishna Cherukuri, Ph.D., head, biophysical spectroscopy section, Radiation Biology Branch, NCI; and Peter Choyke, M.D., F.A.C.R., chief, molecular imaging program, Center for Cancer Research, NCI, who will consult on the project.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Vape Haven rejected by Wauwatosa Common Council 10:34 AM

» Consideration overdue: Thievery marring Little Free Libraries 9/16

» Thai-namite plans fall through in East Tosa 9/15

» Preps football photos of the week: Sept. 12 9/12

» Chili'n on the Ave. is Saturday 9/12

» DSW Designer Shoe Warehouse opens tomorrow at Mayfair Collection 9/9

» TosaFest fight had no arrests or reported injuries, police say 9/9

» E-Cigarette store Vape Haven rejected by Tosa Plan Commission 9/8

» 10 Days in Tosa starts today 9/8

» 'Chaotic' scene at TosaFest limited to one area, mayor says 9/7

» Preps football photos of the week: Sept. 5 9/7

» Unruly teens disrupt Tosa Fest Updated:  9/6

» See inside Wisconsin International Academy Saturday 9/5

» Athleta coming to Mayfair 9/2

» Preps football photos of the week: Aug. 29 8/29

» Tosa West's Purifoy, big plays spark 35-15 win 8/29

» 88-year-old passenger dies after three-car crash in Tosa 8/29

» Nordstrom at Mayfair is planning a restaurant, Ruscello, and a coffee bar 8/29

» Police say train accident was 'apparent suicide' by Oak Creek man 8/28

» Milwaukee gets its first green bike lane installed in Riverwest Updated:  8/27

» Mayfair Applebee's closes after 24 years in business 8/27

» Second design workshop for Tosa skate park is Thursday 8/26

» Former Wauwatosa priest pleads not guilty to embezzlement charges 8/26

» The social media story of Wauwatosa West at Wauwatosa East football 8/23

» Trojans rule the city another year 8/22

View All Posts Got a tip? Welcome rss
Deal Watch - Milwaukee

Milwaukee's Best Discounts & Deals

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

Local Business Directory

CONNECT