Researchers to explore new treatments for pancreatic cancer

July 18, 2014

The Medical College of Wisconsin (MCW) has received a five-year, $2.6 million grant from the National Institutes of Health’s National Cancer Institute to study new therapeutic approaches to treat pancreatic cancer.

Michael Dwinell, Ph.D., associate professor of microbiology and molecular genetics at MCW; and Balaraman Kalyanaraman, Ph.D., Harry R. & Angeline E. Quadracci Professor in Parkinson’s Research and the professor and chairman of biophysics at MCW; are co-principal investigators of the grant.

About 46,000 people in the United States will be diagnosed with pancreatic cancer this year. Pancreatic ductal carcinoma, which comprises 90 percent of those cases, is a highly aggressive cancer. A combination of radiation, chemotherapy and surgical options can extend survival time, but there is no consistently successful treatment.

Emerging research in cancer therapy is focused on exploiting the differences between cancer cell metabolism and normal cell metabolism. Metastasis of cancer, or the proliferation of cancerous cells, is the mechanism by which cancer spreads through the body, eventually leading to the patient’s death.

In this project, the researchers will work to develop new methods of slowing or halting the metastasis of cancer cells by investigating a combination of energy metabolism inhibitors with relatively nontoxic mitochondria- targeted drugs. The results will advance researchers’ understanding of the roles of metabolism and energy in pancreatic cancer malignancy. Further, it could lead to the design and testing of new drugs that would halt the energy production of malignant cells, and ultimately lead to new therapies to treat pancreatic cancer.

Other MCW investigators involved in the research include Susan Tsai, M.D., M.H.S., assistant professor of surgery (co-investigator); Douglas Evans, M.D., Donald C. Ausman Family Foundation Professor chairman of surgery at MCW (consultant); Alexander Craig Mackinnon, M.D., Ph.D., assistant professor of pathology at MCW (consultant). Other MCW personnel include Gang Cheng, Ph.D., research scientist I in biophysics; Jacek Zielonka, Ph.D., research scientist II in biophysics; Ishan Roy, research assistant in the Medical Student Training Program; Donna McAllister, research associate I in biophysics and microbiology and molecular genetics, and Kris Dilkey, laboratory technician III in microbiology and molecular genetics.

This project will also be conducted with the National Cancer Institute intramural researchers Murali Krishna Cherukuri, Ph.D., head, biophysical spectroscopy section, Radiation Biology Branch, NCI; and Peter Choyke, M.D., F.A.C.R., chief, molecular imaging program, Center for Cancer Research, NCI, who will consult on the project.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Fat Tuesday: How Wauwatosa celebrated 02:28 PM

» Tosa officers return to work following police-involved shooting 12:24 PM

» As trial begins, man pleads guilty to shooting Wauwatosa police officer Updated:  2/8

» Tosa's All-City Read well underway, more events to come 2/8

» Wauwatosa Revolving Loan Fund celebrates 25 years 2/8

» Milwaukee Co. Zoo welcomes two new lionesses 2/8

» Updated rankings of area prep boys and girls basketball teams and players 2/8

» Wauwatosa West boys basketball team defeats Shorewood, South Milwaukee 2/3

» Marquette gets revenge with 75-55 victory over Wauwatosa East boys 2/3

» Wauwatosa East's Stewart, Green combine for 49 points in win over Brookfield Central 2/3

» Wauwatosa West girls basketball team loses road games to Shorewood, South Milwaukee 2/3

» Wauwatosa Hurricanes finish second at Bob White Swimming Invitational 2/3

» Wauwatosa Tosa girls basketball team drops tough decisions to Lancers, Chargers 2/3

» Pewaukee whips Wauwatosa wrestlers to take first in conference 2/3

» Positive and uplifting stories in suburban Milwaukee and Lake Country in January 2/1

» Eastbound Blue Mound Road reopens in Wauwatosa Updated:  1/29

» Video: Tosa Top 5: Five things you need to know in Wauwatosa this week 1/28

» Milwaukee Co. launches coyote tracking program in Tosa, West Allis 1/28

» Wauwatosa wrestlers beat South Milwaukee, take third in Janssen Invite 1/27

» Bailey Berlin's free throws give Wauwatosa East win over Tosa West 1/27

» Wauwatosa East girls nip Brookfield East, 52-51, for big GMC victory 1/27

» Wauwatosa West girls basketball team beats Greenfield, snaps 8-game losing streak 1/27

» Wauwatosa Hurricanes sweep St. Thomas More/St. Francis, 144-30 1/27

» Wauwatosa West boys basketball team crushes Greenfield, 76-45 1/27

» Fun-loving Shorewood girls basketball team routs Tosa West, 60-34 1/26

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporters Rory Linnane or Rachel Minske explore the closed down and closed off parts of Wauwatosa.

Advertisement

Election center 2016

Election overage from from the MyCommunityNow coverage area covering suburban Milwaukee County and the eastern half of Waukesha County.

Suburban Milwaukee election center 2016

Local Business Directory

CONNECT