NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
36°
H 54° L 30°
Clear | 0MPH

Transforming skin cells into liver cells

July 7, 2014

The Medical College of Wisconsin (MCW) has received a five-year, $2.1 million dollar grant from the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases to advance work pioneered at MCW in which human skin cells are converted into liver cells, and to identify the molecular mechanisms of liver cell development.

Stephen Duncan, D.Phil., the Marcus Professor of Human and Molecular Genetics and director of the MCW Program in Regenerative Medicine and Stem Cell Biology, is the primary investigator of the grant. Dr. Duncan’s faculty appointment is in the department of cell biology, neurobiology and anatomy where the work will be conducted.

More than 30 million Americans have liver disease, and the causes range from genetics, to viruses such as hepatitis C, cancer, nonalcoholic fatty liver disease, and cirrhosis caused by alcoholism.

Dr. Duncan has shown previously that it is possible to produce liver cells, or hiHeps, from human induced pluripotent stem cells that were once simply adult skin cells. Those hiHeps have been used to model infectious liver disease, inborn liver errors, and other liver problems. The procedure appears to closely mirror the development of the liver that occurs during normal growth of the liver in unborn babies.

In this project, Dr. Duncan’s team will use the cell culture model to unravel the complex molecular mechanisms that underlie human liver development—the “why” behind the differentiation and development of a liver.
The experiments are designed to reveal the specific molecular events that occur during that development, which will allow the team to study inborn errors of liver metabolism, and possibly would allow the identification of methods to correct liver diseases.

Ultimately, the project will significantly advance understanding of the molecular basis of liver cell formation, and help realize the full potential of induced adult pluripotent stem cells in the study and treatment of liver disease.

This project is funded by NIH grant R01DK102716-01.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Poll: Which area team will win a state football title? 09:00 AM

» Wauwatosa negotiating financial aid for Underwood apartments 10/22

» T.J. Maxx opening Oct. 30 in Wauwatosa 10/20

» Across Wisconsin, uneven property assessments fly in the face of fairness Updated:  10/19

» Preps football photos of the week: Week 9 10/17

» 500 free winter emergency kits given away at Mayfair tomorrow 10/17

» Camp Bar Tosa opens Saturday 10/17

» The Malt Shoppe grand opening party is Oct. 24-26 10/15

» JCPenney Furniture Outlet receives bomb threat 10/15

» Former Maharaja partner plans Indian restaurant for Wauwatosa 10/13

» New antique shop could replace Twirly Birds in Wauwatosa Village 10/13

» Preps football photos of the week: Week 8 10/10

» ID not required for voting 10/10

» Corner Bakery announces Oct. 20 opening 10/9

» Pizza Man to open second location at The Mayfair Collection 10/9

» Submit election letters now: deadline is Oct. 20 10/9

» No injuries in Wauwatosa house fire Sunday night 10/6

» Preps football photos of the week: Week 7 10/3

» Motorcyclist killed in East Tosa crash identified 10/3

» Police respond to two bomb threats at Kmart in Wauwatosa 10/3

» Man killed in Hwy. 45 crash identified, other driver arrested 10/1

» 'Rollover ejection crash' kills one, closes Hwy. 45 lanes for 5 hours Updated:  9/30

» East Tosa BID plan rejected 9/30

» Bankruptcy judge approves sale of YMCA properties 9/30

» Man killed in rollover crash on Highway 45 in Wauwatosa 9/30

View All Posts Got a tip? Welcome rss
Deal Watch - Milwaukee

Milwaukee's Best Discounts & Deals

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

Local Business Directory

CONNECT