NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
59°
H 66° L 52°
Clear | 5MPH

Transforming skin cells into liver cells

July 7, 2014

The Medical College of Wisconsin (MCW) has received a five-year, $2.1 million dollar grant from the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases to advance work pioneered at MCW in which human skin cells are converted into liver cells, and to identify the molecular mechanisms of liver cell development.

Stephen Duncan, D.Phil., the Marcus Professor of Human and Molecular Genetics and director of the MCW Program in Regenerative Medicine and Stem Cell Biology, is the primary investigator of the grant. Dr. Duncan’s faculty appointment is in the department of cell biology, neurobiology and anatomy where the work will be conducted.

More than 30 million Americans have liver disease, and the causes range from genetics, to viruses such as hepatitis C, cancer, nonalcoholic fatty liver disease, and cirrhosis caused by alcoholism.

Dr. Duncan has shown previously that it is possible to produce liver cells, or hiHeps, from human induced pluripotent stem cells that were once simply adult skin cells. Those hiHeps have been used to model infectious liver disease, inborn liver errors, and other liver problems. The procedure appears to closely mirror the development of the liver that occurs during normal growth of the liver in unborn babies.

In this project, Dr. Duncan’s team will use the cell culture model to unravel the complex molecular mechanisms that underlie human liver development—the “why” behind the differentiation and development of a liver.
The experiments are designed to reveal the specific molecular events that occur during that development, which will allow the team to study inborn errors of liver metabolism, and possibly would allow the identification of methods to correct liver diseases.

Ultimately, the project will significantly advance understanding of the molecular basis of liver cell formation, and help realize the full potential of induced adult pluripotent stem cells in the study and treatment of liver disease.

This project is funded by NIH grant R01DK102716-01.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Leff's Lucky Town in Wauwatosa considers kitchen expansion 02:25 PM

» Walker plans to file for president today 10:46 AM

» Driver ejected from car after hitting tree in Wauwatosa 7/1

» Monarch habitat on the mend in Wauwatosa 7/1

» Wauwatosa Police Report: June 21-27 7/1

» Wauwatosa detective home from hospital after shooting 7/1

» Thai-namite plans new location in Wauwatosa's former City Market building Updated:  6/30

» Sports Notes: July 2, 2015 6/30

» Wauwatosa police say woman was dragged across parking lot in purse robbery 6/30

» Thirsty Duck brings duckpin bowling to Wauwatosa Updated:  6/30

» Kate Spade New York store to open at Mayfair Mall 6/29

» Suspect charged in shooting of Wauwatosa police officer Updated:  6/25

» Police identify Wauwatosa detective shot, injured in Milwaukee 6/23

» Tosa West student attended journalism conference in D.C. 6/23

» Wauwatosa school board approves 8 percent levy hike under preliminary budget 6/23

» Suspect in Tosa detective shooting charged in earlier armed robbery 6/22

» 2015 4th of July events in suburban Milwaukee 6/22

» Tip leads police to suspect in shooting of Wauwatosa detective Updated:  6/20

» Suspect in shooting of Tosa detective eludes police Updated:  6/19

» Benji's Deli plans to open next to Camp Bar in Wauwatosa 6/19

» Indulgence Chocolatiers now open in Wauwatosa 6/19

» Wauwatosa police detective shot in Milwaukee 6/19

» Venturis roll out old menu with new spin at Tosa Bowl and Bun 6/16

» In 'one last try' to preserve Wauwatosa's Eschweiler buildings, Mandel seeks proposals 6/15

» Three Tosa schools recognized for positive behavioral implementations 6/15

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

2015 Writing Contest

 

(Click image for details)

Advertisement

Local Business Directory

CONNECT