NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
23°
H 23° L 14°
Cloudy | 6MPH

Transforming skin cells into liver cells

July 7, 2014

The Medical College of Wisconsin (MCW) has received a five-year, $2.1 million dollar grant from the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases to advance work pioneered at MCW in which human skin cells are converted into liver cells, and to identify the molecular mechanisms of liver cell development.

Stephen Duncan, D.Phil., the Marcus Professor of Human and Molecular Genetics and director of the MCW Program in Regenerative Medicine and Stem Cell Biology, is the primary investigator of the grant. Dr. Duncan’s faculty appointment is in the department of cell biology, neurobiology and anatomy where the work will be conducted.

More than 30 million Americans have liver disease, and the causes range from genetics, to viruses such as hepatitis C, cancer, nonalcoholic fatty liver disease, and cirrhosis caused by alcoholism.

Dr. Duncan has shown previously that it is possible to produce liver cells, or hiHeps, from human induced pluripotent stem cells that were once simply adult skin cells. Those hiHeps have been used to model infectious liver disease, inborn liver errors, and other liver problems. The procedure appears to closely mirror the development of the liver that occurs during normal growth of the liver in unborn babies.

In this project, Dr. Duncan’s team will use the cell culture model to unravel the complex molecular mechanisms that underlie human liver development—the “why” behind the differentiation and development of a liver.
The experiments are designed to reveal the specific molecular events that occur during that development, which will allow the team to study inborn errors of liver metabolism, and possibly would allow the identification of methods to correct liver diseases.

Ultimately, the project will significantly advance understanding of the molecular basis of liver cell formation, and help realize the full potential of induced adult pluripotent stem cells in the study and treatment of liver disease.

This project is funded by NIH grant R01DK102716-01.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Wrong-way driver identified as person killed in I-94 crash 1/24

» Wauwatosa offers 'Citizen's Academy' course 1/21

» Packers playoff run prompts fond memories 1/18

» Suburban Selfies contest extended through Jan. 25; two selfie solutions to get you started! 1/15

» Wauwatosa school district adds computer science course 1/14

» Wauwatosa man dead after crash on Miller Park Way 1/12

» Wauwatosa stamp factory to become shopping center 1/12

» Mayfair Collection developer buys nearby site for retail project Updated:  1/8

» Plaque honors memory of Wauwatosa Police Officer Jennifer Sebena 1/8

» Three candidates vie to represent Wauwatosa on Milwaukee County Board 1/7

» Developers reveal plans for housing at Wauwatosa's Mayfair Collection 1/6

» Milwaukee man dead after crash in Wauwatosa 1/6

» Coast Guard member gets 5 months confinement for assault 1/6

» Friday deadline for Wauwatosa Distinguished Citizen nominations 1/5

» Wauwatosans organize rally in support of local police 1/2

» Brown's tip in makes Wauwatosa West upset winner 12/31

» Wauwatosa East to establish Athletic Hall of Fame in 2015 12/30

» Wauwatosa's All-City Read invites students, residents for essay contest 12/30

» Nordstrom to open Oct. 23, 2015 at Mayfair 12/30

» Suburban Selfies is back! Win a $200 dinner! 12/24

» Dontre Hamilton protesters rally at Bradley Center, Mayfair Updated:  12/23

» Protesters stage 'die-in' at Mayfair mall in support of Dontre Hamilton 12/23

» Westbound I-94 near Miller Park to close for 31 hours beginning Friday night 12/18

» Woman drives drunk to pick up drunken driver from police station 12/10

» Suspects of five related burglaries in Wauwatosa arrested, charged 12/9

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.


Local Business Directory

CONNECT