How safe is anesthesia for children?

July 2, 2014

The Medical College of Wisconsin (MCW) has received a five-year, $1.4 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to determine the role of microRNAs in damage to the nervous system in some children and fetuses who have been exposed to anesthetic.

Xiaowen Bai, M.D., Ph.D., assistant professor of anesthesiology, is the principal investigator of the grant. Zeljko J. Bosnjak, Ph.D., professor of anesthesiology and physiology; and Allison D. Ebert, Ph.D., assistant professor of cell biology, neurobiology and anatomy are co-investigators.

Evidence suggests that general anesthetics induce neuronal cell death followed by long-term memory and learning disability in animals, which raises serious concerns about the safety of obstetric and pediatric anesthesia.

MicroRNAs are endogenous, small, non-coding RNAs that are powerful regulators in physiology and disease through prevention of target gene expression. In this project, Dr. Bai and her team will examine the role of microRNAs in anesthetic-induced neurotoxicity in mice and translate the findings to humans using stem cell-derived neurons, which will help prevent the effects of anesthetic-induced neurotoxicity by identifying microRNA signaling pathways.

The ultimate goal of this project is to develop neuroprotection strategies to increase the safety of anesthesia in pediatric patients.

This project is funded by NIH grant 1R01GM112696-01.

Community Watch

» Protest over fatal shooting forces brief closure of Mayfair Mall 7/23

» Reports into fatal Wauwatosa police shooting delivered to DA 7/22

» Social media story on the storms rolling through Milwaukee area 7/21

» Business Spotlight: Cranky Al's has grown from desperation to a Wauwatosa institution Updated:  7/20

» Initial Reaction Podcast: Wisconsin Badgers football, WIFCA All-Star game 7/20

» Michaelis leads Wauwatosa East past rival West in regional 7/20

» Milwaukee County Chargers earn overtime win over Muskego 7/20

» Activists push DA for disclosure on police killing in Wauwatosa 7/19

» Video: How a Pokémon Go newbie experienced the craze playing in Wauwatosa Updated:  7/19

» Tosa police, firefighters celebrated during First Responders Fest 7/18

» Ray's Wine & Spirits in Tosa celebrates 55 years with public party 7/15

» Wauwatosa's Relay for Life event slated for July 22 7/14

» Wauwatosa Mayor Kathy Ehley receives award for business leadership 7/14

» Video: Mayfair Collection's Bartolotta restaurants billed as 'triple threat' Updated:  7/14

» Bus rapid transit route clears two hurdles 7/13

» A look at the French restaurant Cafe Grace, opening Tuesday in Wauwatosa 7/13

» Wauwatosa West baseball team drops four of last five games 7/12

» Wauwatosa East baseball team falls to Marquette in Greater Metro semifinals 7/12

» Coalition for Justice, Black Lives Matter protest in Milwaukee, Tosa Updated:  7/12

» Second demonstration in less than a week held at Mayfair 7/12

» Milwaukee County Chargers win first game 7/12

» Wauwatosa East's Kelnhofer to play in All-Star Game 7/12

» Milwaukee County Zoo announces arrival of new female orangutan 7/12

» Zoological Society of Milwaukee announces new president, CEO 7/12

» Initial Reaction Podcast: WIAA state summer baseball tournament preview Updated:  7/12

View All Posts Got a tip? Welcome rss

Best Summer Ever

 

We've made it easy for you to get out and go this summer. From hitting the trails for a bike ride or walk, to where to find beer gardens in the area, to the best places to swim in Waukesha County to the best summer drinks and summer reads, check out our 2016 summer guide.

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where our Wauwatosa reporter explores the closed down and closed off parts of Wauwatosa.

Advertisement

CONNECT