NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
48°
H 64° L 48°
Rain | 22MPH

How safe is anesthesia for children?

July 2, 2014

The Medical College of Wisconsin (MCW) has received a five-year, $1.4 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to determine the role of microRNAs in damage to the nervous system in some children and fetuses who have been exposed to anesthetic.

Xiaowen Bai, M.D., Ph.D., assistant professor of anesthesiology, is the principal investigator of the grant. Zeljko J. Bosnjak, Ph.D., professor of anesthesiology and physiology; and Allison D. Ebert, Ph.D., assistant professor of cell biology, neurobiology and anatomy are co-investigators.

Evidence suggests that general anesthetics induce neuronal cell death followed by long-term memory and learning disability in animals, which raises serious concerns about the safety of obstetric and pediatric anesthesia.

MicroRNAs are endogenous, small, non-coding RNAs that are powerful regulators in physiology and disease through prevention of target gene expression. In this project, Dr. Bai and her team will examine the role of microRNAs in anesthetic-induced neurotoxicity in mice and translate the findings to humans using stem cell-derived neurons, which will help prevent the effects of anesthetic-induced neurotoxicity by identifying microRNA signaling pathways.

The ultimate goal of this project is to develop neuroprotection strategies to increase the safety of anesthesia in pediatric patients.

This project is funded by NIH grant 1R01GM112696-01.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Research Park leadership changing with Drew's retirement 5/29

» Monarch-friendly plants for sale in Wauwatosa Sunday 5/29

» Milwaukee man charged for causing fatal rollover crash in Wauwatosa 5/28

» Run Tosa Run raises $3K for Ronald McDonald House 5/26

» Longfellow hosting Wauwatosa's Memorial Day ceremony Monday 5/21

» Choice school, dry cleaning issues held for more discussion in Wauwatosa 5/20

» Parents rally after lawmakers expand vouchers 5/20

» Wauwatosa approves conceptual design for pocket park on North Avenue Updated:  5/20

» Wauwatosa hotel site sells for $925,000 5/20

» Tosa Tonight releases lineup for summer concert series 5/19

» Wauwatosa School Board approves raises for teachers, administrators and staff 5/19

» Wauwatosa Avenue lane to close over Memorial Day weekend 5/18

» Residents invited to help redesign streets, parks in Wauwatosa Village 5/15

» Wauwatosa alderman pulls proposal to shrink common council 5/15

» Police arrest teens for prowling after foot chase through Wauwatosa Updated:  5/14

» Initial Reaction Podcast: Massive overhaul of area conferences could be afoot 5/13

» Beer garden at Hoyt Park in Tosa reopens Wednesday, may go indoors too 5/12

» Winter's not through with us yet 5/12

» Wauwatosa mayor named to MMSD governing commission 5/11

» Police say motorcyclist riding without helmet injured in Wauwatosa collision 5/7

» Ex-Wauwatosa school board vice president 'disheartened by political dissonance' in community Updated:  5/6

» Wauwatosa celebrating Bike to School Day Wednesday 5/5

» Wauwatosa alderman proposes cutting four seats on Common Council 5/4

» East kickers blank Tosa West, 2-0 5/2

» Investigation: Family behind collapsed Falls building has a history of neglecting properties Updated:  5/1

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

2015 Writing Contest

 

(Click image for details)

Local Business Directory

CONNECT