The Medical College of Wisconsin (MCW) has received a five-year, $1.4 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to determine the role of microRNAs in damage to the nervous system in some children and fetuses who have been exposed to anesthetic.
Xiaowen Bai, M.D., Ph.D., assistant professor of anesthesiology, is the principal investigator of the grant. Zeljko J. Bosnjak, Ph.D., professor of anesthesiology and physiology; and Allison D. Ebert, Ph.D., assistant professor of cell biology, neurobiology and anatomy are co-investigators.
Evidence suggests that general anesthetics induce neuronal cell death followed by long-term memory and learning disability in animals, which raises serious concerns about the safety of obstetric and pediatric anesthesia.
MicroRNAs are endogenous, small, non-coding RNAs that are powerful regulators in physiology and disease through prevention of target gene expression. In this project, Dr. Bai and her team will examine the role of microRNAs in anesthetic-induced neurotoxicity in mice and translate the findings to humans using stem cell-derived neurons, which will help prevent the effects of anesthetic-induced neurotoxicity by identifying microRNA signaling pathways.
The ultimate goal of this project is to develop neuroprotection strategies to increase the safety of anesthesia in pediatric patients.
This project is funded by NIH grant 1R01GM112696-01.
Your link to the biggest stories in the suburbs delivered Thursday mornings.
Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter Get the Newsletter!
- BBB to Hold Free Fall Shredding Events
- Travel Around the World at the 71st Annual Holiday Folk Fair International
- Milwaukee/NARI’s Tips for Easier Fall Lawn & Garden Maintenance
- Attendance at Seventh Annual Multi-Chamber Networking Event Tops Two Hundred Fifty Members
- Meet Your New Employer at the Workforce Development Center's Autumn Recruitment Fair
- Fall Open House at Heritage Court in Menomonee Falls
- St. Robert School Annual Rummage Sale October 3 and 4
- Bartelt Wins Two MBA Achievement Awards
- HMGC designated to run Undiagnosed Disease Network sequencing center
- New parking lot kicks off $1 million in WAUMC capital improvements