Our privacy policy has changed. By using this site, you agree to the Privacy Policy and Terms of Use. Dismiss

How safe is anesthesia for children?

July 2, 2014

The Medical College of Wisconsin (MCW) has received a five-year, $1.4 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to determine the role of microRNAs in damage to the nervous system in some children and fetuses who have been exposed to anesthetic.

Xiaowen Bai, M.D., Ph.D., assistant professor of anesthesiology, is the principal investigator of the grant. Zeljko J. Bosnjak, Ph.D., professor of anesthesiology and physiology; and Allison D. Ebert, Ph.D., assistant professor of cell biology, neurobiology and anatomy are co-investigators.

Evidence suggests that general anesthetics induce neuronal cell death followed by long-term memory and learning disability in animals, which raises serious concerns about the safety of obstetric and pediatric anesthesia.

MicroRNAs are endogenous, small, non-coding RNAs that are powerful regulators in physiology and disease through prevention of target gene expression. In this project, Dr. Bai and her team will examine the role of microRNAs in anesthetic-induced neurotoxicity in mice and translate the findings to humans using stem cell-derived neurons, which will help prevent the effects of anesthetic-induced neurotoxicity by identifying microRNA signaling pathways.

The ultimate goal of this project is to develop neuroprotection strategies to increase the safety of anesthesia in pediatric patients.

This project is funded by NIH grant 1R01GM112696-01.

Community Watch

» Sports Shorts: May 5, 2016 10:48 AM

» Wauwatosa East batters come to life against Brown Deer, Brookfield East 10:39 AM

» Wauwatosa East boys track team finishes fourth at Dan Benson Invite 10:09 AM

» Wauwatosa golfers win Panther Invite 10:04 AM

» Wauwatosa West softball team holds on to nip Port Washington 10:00 AM

» Wauwatosa East girls track team finishes fourth at Dan Benson Invite 09:49 AM

» Adams leads the way for Wauwatosa West girls at Dan Benson Invite 09:44 AM

» Wauwatosa West boys track and field team finishes fifth at Dan Benson Invite 09:28 AM

» Initial Reaction Podcast: Schobert, Watt, Packers and social media foibles of NFL Draft 5/2

» Travis Hudson earns third straight volleyball National Player of the Year Award 5/2

» Wauwatosa East student named 2016 presidential scholar 5/2

» Tosa Tonight announces 2016 concert headliners 5/2

» 360NOW: Wander Wawatosa's village 4/29

» Milwaukee Co. Zoo welcomes new female giraffe calf 4/29

» Video Tosa Top 5: Five things you need to know about in Wauwatosa 4/28

» Wauwatosa seeks volunteers for focus groups on city communication 4/28

» Show about solitary confinement encourages discussion, activism 4/28

» Annual Tosa Night Out celebration will relocate to Milwaukee County Zoo Updated:  4/27

» District leaders question use of Wauwatosa schools as voting locations Updated:  4/27

» Area businesses collaborate to create the 'Cranky Sammie' in East Tosa 4/27

» Wauwatosa Sports Notes: Players sign with colleges, baseball fundraiser, more 4/26

» Wauwatosa West sprinters stand out at Kansas Relays 4/26

» Wauwatosa West' Hannah-Howell, Jefferson shine at Sun Prairie Track Meet 4/26

» Wauwatosa West tennis team wins three of four at Raider/Trojan Invite 4/26

» Wauwatosa golfers finish fifth at first GMC mini meet 4/26

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporters Rory Linnane or Rachel Minske explore the closed down and closed off parts of Wauwatosa.

Advertisement

CONNECT