NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
70°
H 81° L 55°
Clear | 6MPH

What genes cause PHACE syndrome? MCW researcher aims to find out

June 25, 2014

The Medical College of Wisconsin (MCW) and the Children’s Hospital of Wisconsin Research Institute have received a three-year, $1.3 million grant from the National Institutes of Health’s (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases to study the genetic causes of PHACE syndrome, which is characterized by a large facial hemangioma, an abnormal buildup of blood vessels on the face, with other birth defects including abnormalities of the brain, heart, and eyes.

Dawn H. Siegel, M.D., associate professor of dermatology at MCW and a practicing pediatric dermatologist at Children’s Hospital of Wisconsin, is the principal investigator of the grant. Her research focuses on hemangiomas and genetic skin disorders, with particular interest in PHACE syndrome. PHACE is an acronym for posterior fossa malformations–hemangiomas–arterial anomalies–cardiac defects–eye abnormalities. This project will be undertaken by a multi-disciplinary team of experts in dermatology, genetics, neurology, bioinformatics, statistics, and cell biology.
The cause of PHACE syndrome is unknown and is the subject of investigation by researchers at the Children’s Hospital of Wisconsin and elsewhere. The first major goal of this grant is to identify genes involved in the development of PHACE syndrome. Researchers will then use this information to determine which of these genes are associated with the most severe features of this condition, such as heart malformations.

The results of this study will provide an understanding of the genetic basis of PHACE syndrome, and may foster new strategies in the prevention or treatment of this condition and other pediatric hemangiomas.

This research is supported by NIH grant 1R01AR064258-01A1, through the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Leff's Lucky Town in Wauwatosa considers kitchen expansion 7/2

» Walker plans to file for president today 7/2

» Driver ejected from car after hitting tree in Wauwatosa 7/1

» Monarch habitat on the mend in Wauwatosa 7/1

» Wauwatosa Police Report: June 21-27 7/1

» Wauwatosa detective home from hospital after shooting 7/1

» Thai-namite plans new location in Wauwatosa's former City Market building Updated:  6/30

» Sports Notes: July 2, 2015 6/30

» Wauwatosa police say woman was dragged across parking lot in purse robbery 6/30

» Thirsty Duck brings duckpin bowling to Wauwatosa Updated:  6/30

» Kate Spade New York store to open at Mayfair Mall 6/29

» Suspect charged in shooting of Wauwatosa police officer Updated:  6/25

» Police identify Wauwatosa detective shot, injured in Milwaukee 6/23

» Tosa West student attended journalism conference in D.C. 6/23

» Wauwatosa school board approves 8 percent levy hike under preliminary budget 6/23

» Suspect in Tosa detective shooting charged in earlier armed robbery 6/22

» 2015 4th of July events in suburban Milwaukee 6/22

» Tip leads police to suspect in shooting of Wauwatosa detective Updated:  6/20

» Suspect in shooting of Tosa detective eludes police Updated:  6/19

» Benji's Deli plans to open next to Camp Bar in Wauwatosa 6/19

» Indulgence Chocolatiers now open in Wauwatosa 6/19

» Wauwatosa police detective shot in Milwaukee 6/19

» Venturis roll out old menu with new spin at Tosa Bowl and Bun 6/16

» In 'one last try' to preserve Wauwatosa's Eschweiler buildings, Mandel seeks proposals 6/15

» Three Tosa schools recognized for positive behavioral implementations 6/15

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

2015 Writing Contest

 

(Click image for details)

Advertisement

Local Business Directory

CONNECT