MCW researcher to study relationship between nervous system cells and blood flow in brain

June 17, 2014

The Medical College of Wisconsin (MCW) has received a four-year, $1.5 million grant from the National Institutes of Health’s (NIH) National Heart, Lung, and Blood Institute to study how astrocytes, the cells that support neurons in the brain and spinal cord, affect the genetic makeup and function of other cells in the brain.

David R. Harder, Ph.D., professor of physiology, medicine and pediatrics at and associate dean of research at MCW and the Kohler Company Professor in Cardiovascular Research, is the principal investigator of the grant. His research interests focus on the genetic and molecular basis of how the vasculature of the brain self-regulates cerebral blood flow.

Astrocytes are cells in the brain and spinal cord that support neurons through a variety of means, including supplying nutrients and modulating ion concentrations critical to neuronal activity. Astrocytes release a large number of molecules that may affect gene expression in neighboring cells and are thought to be involved in regulation of cerebral blood flow. A major goal of this grant is to analyze this array of released astrocytic factors, and to determine how it may alter the gene expression and function of cells in the brain’s vasculature and of invading tumor cells.

The results of this project will provide further understanding of how blood flow in the brain is maintained and may impact research in related fields, including stroke, hypertension and other pathologies of the nervous system.

This research is supported by NIH grant 2R01HL033833-29.

Community Watch

» Irish Fest gears up for week of classes at Tosa's CelticMKE Center 02:09 PM

» Tosa Skateboarders United hosts first event since opening of new park 01:59 PM

» Friends of Center Street Park will launch new barbecue event July 3 01:15 PM

» Long-tenured sports writer Sky Skibosh heads into retirement, sort of 6/26

» Family, friends of man killed by Wauwatosa officer want answers 6/25

» Tosa man with gun trove to plead guilty of illegal dealing 6/24

» Wauwatosa endorses bus rapid transit route, more approvals needed Updated:  6/23

» Video: Tosa Top 5: Five things you need to know about in Wauwatosa this week 6/23

» Wauwatosa officer fatally shoots man at Madison Park 6/23

» Wauwatosa Public Library announces list of summer events 6/22

» Blood drives scheduled for Milwaukee County during month of July 6/22

» Two lanes on Wauwatosa's Harmonee Bridge to close Thursday 6/22

» Milwaukee Co. Zoo welcomes baby harbor seal, bonobo 6/22

» Teens accused of trying to rob Tosa resident with BB gun Updated:  6/22

» Hidden Tosa: Inside the Wauwatosa Police Department 6/22

» Offense holding back Wauwatosa West baseball team 6/21

» Wauwatosa East baseball wins four conference games 6/21

» Former Wauwatosa West star Austin Jones drafted by Chicago Cubs in 26th round 6/21

» East Tosa Gran Prix returns to Wauwatosa June 26 6/21

» Wauwatosa School Board votes to give teachers a bump in pay Updated:  6/20

» New records for Tosa Swim Club 6/20

» Tosa customers temporarily lose power after squirrel causes blown fuse 6/20

» Video: VISIT Milwaukee, city of Wauwatosa launch new tourism video 6/20

» Mayfair mall's Sephora draws police attention since February Updated:  6/17

» Pool at Hoyt Park running again following mid-week mechanical failure 6/17

View All Posts Got a tip? Welcome rss

Best Summer Ever

 

We've made it easy for you to get out and go this summer. From hitting the trails for a bike ride or walk, to where to find beer gardens in the area, to the best places to swim in Waukesha County to the best summer drinks and summer reads, check out our 2016 summer guide.

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where our Wauwatosa reporter explores the closed down and closed off parts of Wauwatosa.

Advertisement

CONNECT