The Medical College of Wisconsin (MCW) has received a five-year, $1.6 million grant from the National Institutes of Health’s (NIH) National Institute on Drug Abuse to study the mechanisms by which phosphodiesterase (PDE) inhibitors reduce addictive behaviors.
Qing-Song Liu, Ph.D., associate professor of pharmacology and toxicology at MCW, is the principal investigator of the grant.
Research in the Liu laboratory focuses on understanding how cocaine alters neuronal communication and the neural circuits that make up the brain’s “reward” centers. These so-called reward centers are key targets of many drugs of abuse.
Substance abuse is a serious public health problem and there are currently no FDA-approved medications for treating cocaine addiction. PDE inhibitors have been shown to be effective in the treatment or management of non-addiction conditions, such as respiratory disease and depression, and have been demonstrated to counteract addictive behaviors. PDE inhibitors are therefore promising candidates as anti-addiction medications with additional potential health benefits. The major goal of this grant is to identify the cellular pathways and components by which PDE inhibitors reduce addictive behaviors.
The results of this project will advance the understanding of the mechanisms of addiction and may impact treatment strategies for substance abuse.
This project is supported by NIH grant number 1R01DA035217-01A1.
Your link to the biggest stories in the suburbs delivered Thursday mornings.
Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter Get the Newsletter!
- Sky Zone Launches Fitness Challenge
- Ramirez Family Foundation pledges $1 million to improve healthcare quality and reduce costs
- Alicia, My Story
- 29th Annual Easter Egg Hunt
- NEWCASTLE PLACE TO HOST MEMORIES IN THE MAKING® ART SHOWCASE
- Holy Week Celebration Services at Trinity UCC
- Prata Duo To Present Free Concert
- MCW researchers to study medication to treat traumatic brain injury
- Two Comedy Shows benefit local military charities
- 15 Companies Join Milwaukee/NARI Home Improvement Council