NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
63°
H ° L °
Clear | 0MPH

Exploring new methods to fight drug addiction

June 13, 2014

The Medical College of Wisconsin (MCW) has received a five-year, $1.6 million grant from the National Institutes of Health’s (NIH) National Institute on Drug Abuse to study the mechanisms by which phosphodiesterase (PDE) inhibitors reduce addictive behaviors.

Qing-Song Liu, Ph.D., associate professor of pharmacology and toxicology at MCW, is the principal investigator of the grant.

Research in the Liu laboratory focuses on understanding how cocaine alters neuronal communication and the neural circuits that make up the brain’s “reward” centers. These so-called reward centers are key targets of many drugs of abuse.

Substance abuse is a serious public health problem and there are currently no FDA-approved medications for treating cocaine addiction. PDE inhibitors have been shown to be effective in the treatment or management of non-addiction conditions, such as respiratory disease and depression, and have been demonstrated to counteract addictive behaviors. PDE inhibitors are therefore promising candidates as anti-addiction medications with additional potential health benefits. The major goal of this grant is to identify the cellular pathways and components by which PDE inhibitors reduce addictive behaviors.

The results of this project will advance the understanding of the mechanisms of addiction and may impact treatment strategies for substance abuse.

This project is supported by NIH grant number 1R01DA035217-01A1.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Leff's Lucky Town in Wauwatosa considers kitchen expansion 7/2

» Walker plans to file for president today 7/2

» Driver ejected from car after hitting tree in Wauwatosa 7/1

» Monarch habitat on the mend in Wauwatosa 7/1

» Wauwatosa Police Report: June 21-27 7/1

» Wauwatosa detective home from hospital after shooting 7/1

» Thai-namite plans new location in Wauwatosa's former City Market building Updated:  6/30

» Sports Notes: July 2, 2015 6/30

» Wauwatosa police say woman was dragged across parking lot in purse robbery 6/30

» Thirsty Duck brings duckpin bowling to Wauwatosa Updated:  6/30

» Kate Spade New York store to open at Mayfair Mall 6/29

» Suspect charged in shooting of Wauwatosa police officer Updated:  6/25

» Police identify Wauwatosa detective shot, injured in Milwaukee 6/23

» Tosa West student attended journalism conference in D.C. 6/23

» Wauwatosa school board approves 8 percent levy hike under preliminary budget 6/23

» Suspect in Tosa detective shooting charged in earlier armed robbery 6/22

» 2015 4th of July events in suburban Milwaukee 6/22

» Tip leads police to suspect in shooting of Wauwatosa detective Updated:  6/20

» Suspect in shooting of Tosa detective eludes police Updated:  6/19

» Benji's Deli plans to open next to Camp Bar in Wauwatosa 6/19

» Indulgence Chocolatiers now open in Wauwatosa 6/19

» Wauwatosa police detective shot in Milwaukee 6/19

» Venturis roll out old menu with new spin at Tosa Bowl and Bun 6/16

» In 'one last try' to preserve Wauwatosa's Eschweiler buildings, Mandel seeks proposals 6/15

» Three Tosa schools recognized for positive behavioral implementations 6/15

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

2015 Writing Contest

 

(Click image for details)

Advertisement

Local Business Directory

CONNECT