Our privacy policy has changed. By using this site, you agree to the Privacy Policy and Terms of Use. Dismiss

Exploring new methods to fight drug addiction

June 13, 2014

The Medical College of Wisconsin (MCW) has received a five-year, $1.6 million grant from the National Institutes of Health’s (NIH) National Institute on Drug Abuse to study the mechanisms by which phosphodiesterase (PDE) inhibitors reduce addictive behaviors.

Qing-Song Liu, Ph.D., associate professor of pharmacology and toxicology at MCW, is the principal investigator of the grant.

Research in the Liu laboratory focuses on understanding how cocaine alters neuronal communication and the neural circuits that make up the brain’s “reward” centers. These so-called reward centers are key targets of many drugs of abuse.

Substance abuse is a serious public health problem and there are currently no FDA-approved medications for treating cocaine addiction. PDE inhibitors have been shown to be effective in the treatment or management of non-addiction conditions, such as respiratory disease and depression, and have been demonstrated to counteract addictive behaviors. PDE inhibitors are therefore promising candidates as anti-addiction medications with additional potential health benefits. The major goal of this grant is to identify the cellular pathways and components by which PDE inhibitors reduce addictive behaviors.

The results of this project will advance the understanding of the mechanisms of addiction and may impact treatment strategies for substance abuse.

This project is supported by NIH grant number 1R01DA035217-01A1.

Community Watch

» Suburban Milwaukee and Lake Country's 2016 WIAA State Track and Field Meet Special Section Updated:  03:00 PM

» With peers downsizing, couple takes on ultimate fixer-upper 5/28

» Name revealed of new female giraffe at Milwaukee Co. Zoo 5/26

» Wauwatosa law enforcement honors fallen officers during national bike tour Updated:  5/26

» Tosa Top 5: Five things you need to know about in Wauwatosa this week 5/25

» Wauwatosa West boys finish fourth at Woodland Relays 5/25

» Wauwatosa West girls soccer team wins Woodland Conference championship 5/25

» Wauwatosa East soccer team splits two games, loses Lily Brock to injury 5/25

» Wauwatosa East girls finish seventh at GMC Outdoor Track and Field Meet 5/25

» Wauwatosa East boys fourth at GMC Outdoor Track and Field Meet 5/25

» State Street road work may be the biggest headache this year in Wauwatosa 5/25

» Wauwatosa Sports Notes: May 26, 2016 5/24

» Milwaukee County Chargers defeat Bulldogs in exhibition opener, 20-6 5/24

» Wauwatosa officer rescues seven ducklings trapped in storm sewer 5/24

» Initial Reaction: Talking with star Waukesha soccer players Dani Rhodes, Emily Cervantes Updated:  5/24

» Wauwatosa Police Report: May 15 - 21 5/24

» Wauwatosa West girls track team runs away with Woodland Outdoor title 5/24

» Video: Reporter takes us along the 2016 Run Tosa Run 5/23

» Tosa Top 5: Five things you need to know about in Wauwatosa this week 5/20

» Suspects charged in string of armed robberies through Wauwatosa, Milwaukee Updated:  5/19

» New Mayfair GM announces plans for a Z Gallerie furniture store Updated:  5/18

» Wauwatosa East baseball team will rely on defense, depth in 2016 5/18

» Wauwatosa East softball teams beats West Allis Central in twinbill 5/18

» Campus News: May 19 5/18

» Sports Shorts: May 19, 2016 5/18

View All Posts Got a tip? Welcome rss

Best Summer Ever

 

We've made it easy for you to get out and go this summer. From hitting the trails for a bike ride or walk, to where to find beer gardens in the area, to the best places to swim in Waukesha County to the best summer drinks and summer reads, check out our 2016 summer guide.

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where our Wauwatosa reporter explores the closed down and closed off parts of Wauwatosa.

Advertisement

CONNECT