Our privacy policy has changed. By using this site, you agree to the Privacy Policy and Terms of Use. Dismiss

Statins fail to reduce mortality rates in sepsis patients with acute respiratory distress

May 20, 2014

Despite previously-reported observational and basic science evidence suggesting the use of statins may improve outcomes in patients with sepsis and acute respiratory distress syndrome (ARDS), a double-blinded clinical trial of rosuvastatin in those patients was futile, and the study was halted.

The findings are published in the May 18, 2014 New England Journal of Medicine http://www.nejm.org/doi/full/10.1056/NEJMoa1401520, along with accompanying editorials evaluating the research’s goals and outcomes. The primary investigator and lead author of the study is Jonathon D. Truwit, M.D., professor of medicine and enterprise chief medical officer and senior administrative dean at Froedtert & the Medical College of Wisconsin.

Despite improvements in supportive care for ARDS, the mortality rate remains high, one in four patients die. Sepsis is the major reason patients develop ARDS. Statins have been shown to reduce inflammation and prevent ARDS in basic science studies, and have also been reported in observational studies to improve outcomes in patients with sepsis and ARDS.

In this study, patients received either the rosuvastatin or a placebo, and the study was double-blinded. After 745 of the proposed 1000 patients had been enrolled in the multi-center trial, the study was halted because there was no significant difference between the study groups. Further, the rosuvastatin therapy may have contributed to hepatic and renal organ dysfunction.

“While this therapy did not lead to better outcomes, it is important that we evaluate possible therapies for conditions such as ARDS because it adds to our knowledge about this condition, which has a high mortality rate for patients. The information gathered in this study will guide further basic and clinical research to ultimately improve our care for critically ill patients,” said Dr. Truwit.

The other members of the writing committee for the paper are Gordon R. Bernard, M.D., Vanderbilt University, Nashville; Jay Steingrub, M.D., Baystate Medical Center, Springfield, MA, and Tufts University School of Medicine, Boston; Michael A. Matthay, M.D., and Kathleen D. Liu, M.D., Ph.D., University of California, San Francisco, San Francisco; Timothy E. Albertson, M.D., Ph.D., University of California - Davis, Sacramento; Roy G. Brower, M.D., Johns Hopkins University, and Carl Shanholtz, M.D., and Peter Rock, M.D., University of Maryland — both in Baltimore; Ivor S. Douglas, M.D., Denver Health Medical
Center and University of Colorado, Denver; Bennett P. deBoisblanc, M.D., Louisiana
State University Health Sciences Center, New Orleans; Catherine L. Hough, M.D., University of Washington, Seattle; R. Duncan Hite, M.D., Cleveland Clinic, Cleveland; and B. Taylor Thompson, M.D., Massachusetts General Hospital and Harvard Medical School, Boston.

This study was supported by a grant from the National Institutes of Health’s National Heart, Lung and Blood Institute and the investigator-sponsored study program of AstraZeneca.

Community Watch

» Sports Shorts: May 5, 2016 10:48 AM

» Wauwatosa East batters come to life against Brown Deer, Brookfield East 10:39 AM

» Wauwatosa East boys track team finishes fourth at Dan Benson Invite 10:09 AM

» Wauwatosa golfers win Panther Invite 10:04 AM

» Wauwatosa West softball team holds on to nip Port Washington 10:00 AM

» Wauwatosa East girls track team finishes fourth at Dan Benson Invite 09:49 AM

» Adams leads the way for Wauwatosa West girls at Dan Benson Invite 09:44 AM

» Wauwatosa West boys track and field team finishes fifth at Dan Benson Invite 09:28 AM

» Initial Reaction Podcast: Schobert, Watt, Packers and social media foibles of NFL Draft 5/2

» Travis Hudson earns third straight volleyball National Player of the Year Award 5/2

» Wauwatosa East student named 2016 presidential scholar 5/2

» Tosa Tonight announces 2016 concert headliners 5/2

» 360NOW: Wander Wawatosa's village 4/29

» Milwaukee Co. Zoo welcomes new female giraffe calf 4/29

» Video Tosa Top 5: Five things you need to know about in Wauwatosa 4/28

» Wauwatosa seeks volunteers for focus groups on city communication 4/28

» Show about solitary confinement encourages discussion, activism 4/28

» Annual Tosa Night Out celebration will relocate to Milwaukee County Zoo Updated:  4/27

» District leaders question use of Wauwatosa schools as voting locations Updated:  4/27

» Area businesses collaborate to create the 'Cranky Sammie' in East Tosa 4/27

» Wauwatosa Sports Notes: Players sign with colleges, baseball fundraiser, more 4/26

» Wauwatosa West sprinters stand out at Kansas Relays 4/26

» Wauwatosa West' Hannah-Howell, Jefferson shine at Sun Prairie Track Meet 4/26

» Wauwatosa West tennis team wins three of four at Raider/Trojan Invite 4/26

» Wauwatosa golfers finish fifth at first GMC mini meet 4/26

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporters Rory Linnane or Rachel Minske explore the closed down and closed off parts of Wauwatosa.

Advertisement

CONNECT