NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
75°
H 88° L 70°
Cloudy | 6MPH

Statins fail to reduce mortality rates in sepsis patients with acute respiratory distress

May 20, 2014

Despite previously-reported observational and basic science evidence suggesting the use of statins may improve outcomes in patients with sepsis and acute respiratory distress syndrome (ARDS), a double-blinded clinical trial of rosuvastatin in those patients was futile, and the study was halted.

The findings are published in the May 18, 2014 New England Journal of Medicine http://www.nejm.org/doi/full/10.1056/NEJMoa1401520, along with accompanying editorials evaluating the research’s goals and outcomes. The primary investigator and lead author of the study is Jonathon D. Truwit, M.D., professor of medicine and enterprise chief medical officer and senior administrative dean at Froedtert & the Medical College of Wisconsin.

Despite improvements in supportive care for ARDS, the mortality rate remains high, one in four patients die. Sepsis is the major reason patients develop ARDS. Statins have been shown to reduce inflammation and prevent ARDS in basic science studies, and have also been reported in observational studies to improve outcomes in patients with sepsis and ARDS.

In this study, patients received either the rosuvastatin or a placebo, and the study was double-blinded. After 745 of the proposed 1000 patients had been enrolled in the multi-center trial, the study was halted because there was no significant difference between the study groups. Further, the rosuvastatin therapy may have contributed to hepatic and renal organ dysfunction.

“While this therapy did not lead to better outcomes, it is important that we evaluate possible therapies for conditions such as ARDS because it adds to our knowledge about this condition, which has a high mortality rate for patients. The information gathered in this study will guide further basic and clinical research to ultimately improve our care for critically ill patients,” said Dr. Truwit.

The other members of the writing committee for the paper are Gordon R. Bernard, M.D., Vanderbilt University, Nashville; Jay Steingrub, M.D., Baystate Medical Center, Springfield, MA, and Tufts University School of Medicine, Boston; Michael A. Matthay, M.D., and Kathleen D. Liu, M.D., Ph.D., University of California, San Francisco, San Francisco; Timothy E. Albertson, M.D., Ph.D., University of California - Davis, Sacramento; Roy G. Brower, M.D., Johns Hopkins University, and Carl Shanholtz, M.D., and Peter Rock, M.D., University of Maryland — both in Baltimore; Ivor S. Douglas, M.D., Denver Health Medical
Center and University of Colorado, Denver; Bennett P. deBoisblanc, M.D., Louisiana
State University Health Sciences Center, New Orleans; Catherine L. Hough, M.D., University of Washington, Seattle; R. Duncan Hite, M.D., Cleveland Clinic, Cleveland; and B. Taylor Thompson, M.D., Massachusetts General Hospital and Harvard Medical School, Boston.

This study was supported by a grant from the National Institutes of Health’s National Heart, Lung and Blood Institute and the investigator-sponsored study program of AstraZeneca.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Wauwatosa police will host OWI Task Force deployment 9/2

» WauwaTiki, the tiki bar planned in Tosa, is projecting a November opening 9/2

» Sport Shorts: Sept. 3, 2015 9/2

» Despite loss, Wauwatosa East's defense continues to shine 9/2

» Wauwatosa West football team beats Grafton to start season 2-0 once again 9/2

» Wauwatosa West girls volleyball team takes second at Early Bird tournament 9/2

» Wauwatosa West boys soccer team goes 1-1-1 at Muskego Quad 9/2

» Wauwatosa West girls tennis team nips Vikings 9/2

» Wauwatosa East boys cross-country team has good week 9/2

» Hazardous waste collection event sets Sept. 12 date 9/1

» Tosa Green Summit returns Sept. 12 9/1

» Call for Taste of Tosa cupcake and chili registrants 9/1

» Get interesting prep football tidbits and insights with 'First and Short' blog 8/28

» Hundreds of Tosa residents experienced short power outage Aug. 27 8/28

» Updated weekly rankings of area prep football teams and players 8/27

» Wauwatosa Village valet service tentatively halted on Sundays 8/27

» Wauwatosa East girls cross-country team looking for good things 8/26

» Wauwatosa West returnees should help girls cross-country team 8/26

» Wauwatosa East tennis team has nine returning players 8/26

» Wauwatosa West girls volleyball team has holes to fill 8/26

» Wauwatosa girls golf team fourth at first GMC mini-meet 8/26

» Potter to lead Wauwatosa East boys cross-country team 8/26

» Initial Reaction Podcast: What stood out on the first week of high-school football? 8/25

» Suspected pipe bomb draws neighborhood attention in Wauwatosa Updated:  8/24

» Carey, defense spark New Berlin Eisenhower win 8/24

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

Advertisement

Local Business Directory

CONNECT