NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
55°
H 63° L 48°
Cloudy | 7MPH

Researchers to study naturally-occurring antioxidant

May 9, 2014

The Medical College of Wisconsin (MCW) has received a two-year, $420,000 exploratory grant from the Director’s Office of the National Institutes of Health to investigate antioxidants and why direct administration of antioxidants for human disease have not been more successful.

Julian Lombard, Ph.D., professor of physiology at MCW, is the principal investigator of the grant. Aron Geurts, Ph.D., associate professor of physiology, is co-investigator.

Antioxidants work to neutralize free radicals in the human body, which are associated with cell breakdown and disease. However, clinical trials using direct administration of antioxidants such as vitamin C and vitamin E have not yielded consistent results in combating or preventing disease.

In this study, Dr. Lombard’s team will explore the protein Nrf2, which is a master antioxidant and cell protective protein that is critical in combating oxidant stress. Nrf2 also regulates hundreds of genes related not only to oxidant state, but other physiological processes. Dr. Lombard will characterize cardiovascular and renal variables in rats in which Dr. Geurts’ laboratory has “knocked out” the Nrf2 gene using gene editing technology. Characterization of cardiovascular and renal variables in these Nrf2 “knockout” rats will provide valuable information to help us understand the function of the protein and its effect on physiological systems and organs.

The results of the study will provide not only a better understanding of this key protein, but could also possibly lead to exploration of Nrf2 as a treatment to combat oxidant stress in human disease.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» New Mayfair parking structure to open tonight 10/24

» The Malt Shoppe opens Friday in Wauwatosa 10/23

» Poll: Which area team will win a state football title? 10/22

» Wauwatosa negotiating financial aid for Underwood apartments 10/22

» T.J. Maxx opening Oct. 30 in Wauwatosa 10/20

» Across Wisconsin, uneven property assessments fly in the face of fairness Updated:  10/19

» Preps football photos of the week: Week 9 10/17

» 500 free winter emergency kits given away at Mayfair tomorrow 10/17

» Camp Bar Tosa opens Saturday 10/17

» The Malt Shoppe grand opening party is Oct. 24-26 10/15

» JCPenney Furniture Outlet receives bomb threat 10/15

» Former Maharaja partner plans Indian restaurant for Wauwatosa 10/13

» New antique shop could replace Twirly Birds in Wauwatosa Village 10/13

» Preps football photos of the week: Week 8 10/10

» ID not required for voting 10/10

» Corner Bakery announces Oct. 20 opening 10/9

» Pizza Man to open second location at The Mayfair Collection 10/9

» Submit election letters now: deadline is Oct. 20 10/9

» No injuries in Wauwatosa house fire Sunday night 10/6

» Preps football photos of the week: Week 7 10/3

» Motorcyclist killed in East Tosa crash identified 10/3

» Police respond to two bomb threats at Kmart in Wauwatosa 10/3

» Man killed in Hwy. 45 crash identified, other driver arrested 10/1

» 'Rollover ejection crash' kills one, closes Hwy. 45 lanes for 5 hours Updated:  9/30

» East Tosa BID plan rejected 9/30

View All Posts Got a tip? Welcome rss
Deal Watch - Milwaukee

Milwaukee's Best Discounts & Deals

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

Local Business Directory

CONNECT