NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
68°
H 81° L 57°
Clear | 5MPH

Researchers to study naturally-occurring antioxidant

May 9, 2014

The Medical College of Wisconsin (MCW) has received a two-year, $420,000 exploratory grant from the Director’s Office of the National Institutes of Health to investigate antioxidants and why direct administration of antioxidants for human disease have not been more successful.

Julian Lombard, Ph.D., professor of physiology at MCW, is the principal investigator of the grant. Aron Geurts, Ph.D., associate professor of physiology, is co-investigator.

Antioxidants work to neutralize free radicals in the human body, which are associated with cell breakdown and disease. However, clinical trials using direct administration of antioxidants such as vitamin C and vitamin E have not yielded consistent results in combating or preventing disease.

In this study, Dr. Lombard’s team will explore the protein Nrf2, which is a master antioxidant and cell protective protein that is critical in combating oxidant stress. Nrf2 also regulates hundreds of genes related not only to oxidant state, but other physiological processes. Dr. Lombard will characterize cardiovascular and renal variables in rats in which Dr. Geurts’ laboratory has “knocked out” the Nrf2 gene using gene editing technology. Characterization of cardiovascular and renal variables in these Nrf2 “knockout” rats will provide valuable information to help us understand the function of the protein and its effect on physiological systems and organs.

The results of the study will provide not only a better understanding of this key protein, but could also possibly lead to exploration of Nrf2 as a treatment to combat oxidant stress in human disease.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Children's theater presents free performance of "The Frog Prince" tomorrow night 7/30

» Hawaiian grocery crowd-funds commercial kitchen 7/28

» Wauwatosa School District creates new mobile app 7/25

» Tosa responds to concerns about radiation from water meters 7/25

» Menomonee River 14-year-old drowning victim identified 7/21

» Boy drowns in the Menomonee River at Hoyt Park Updated:  7/19

» Former priest accused of theft again fails to appear in court 7/14

» Police connect teens to recent Milwaukee, Wauwatosa carjackings 7/12

» Briggs & Stratton closing Georgia site, will add 370 jobs in Wauwatosa Updated:  7/10

» Section of I-94 to close entirely July 18-21 7/10

» Wauwatosa man killed in crash that snarled Highway 41 traffic 7/10

» Hundreds in Tosa without power 7/1

» Wauwatosa detective sentenced for drug theft 6/24

» Milwaukee suburbs Fourth of July 2014 celebrations 6/20

» Social media photos of the June 18 storms around Southeast Wisconsin 6/18

» Sewage backups may occur with Wauwatosa sewer at full capacity 6/18

» Corner Bakery coming to Mayfair Collection in Wauwatosa 6/11

» Gunfire leads to police chase in Milwaukee, Wauwatosa 6/11

» Wauwatosa Catholic authorized to become International Baccalaureate World School 6/4

» Waukesha YMCA plans to purchase Wauwatosa site 6/4

» New Milwaukee Bucks owners visit Cranky Al's in Wauwatosa 5/29

» Picnic Basket sandwich shop opens in Wauwatosa 5/22

» State to spend $13.5 million on transit to settle Zoo Interchange suit 5/19

» Gem, mineral and fossil show coming this weekend 5/16

» Malt Shoppe plans to focus on beer, fill growlers in Wauwatosa 5/6

View All Posts Got a tip? Welcome rss
Deal Watch - Milwaukee

Milwaukee's Best Discounts & Deals

Local Business Directory

CONNECT