NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
77°
H 81° L 70°
Partly Cloudy | 13MPH

Identifying Genetic Causes of Kidney Failure

Feb. 27, 2014

The Medical College of Wisconsin has received a four-year, $1.5 million grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to evaluate human genetic variants contributing to end-stage renal disease (ESRD), or kidney failure.

Howard J. Jacob, PhD, Warren P. Knowles Professor of Genetics, professor of physiology and director of the Human and Molecular Genetics Center at the Medical College of Wisconsin (MCW), is the principal investigator.

End stage renal disease usually occurs after years of chronic kidney disease, and is defined by the kidneys’ inability to work at a level required for day-to-day life. The incidence of ESRD has increased by 600 percent since 1980, and in 2010, more than 870,000 people were being treated for ESRD. Common causes include diabetes and high blood pressure, but genetic susceptibility also plays a critical role in the disease process.

In this project, Dr. Jacob’s research team will identify new genes involved in kidney function, evaluate identified variants believed to be involved in kidney failure, and glean a better understanding of the genetic architecture of proteinuria, a condition that is often a precursor of ESRD. New insights into this disease process could identify new therapeutic targets for treating ESRD.

This project is funded by NIH grant 2R01HL069321-09A1.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Preps football photos of the week: Aug. 29 8/29

» Tosa West's Purifoy, big plays spark 35-15 win 8/29

» 88-year-old passenger dies after three-car crash in Tosa 8/29

» Nordstrom at Mayfair is planning a restaurant, Ruscello, and a coffee bar 8/29

» Police say train accident was 'apparent suicide' by Oak Creek man 8/28

» Milwaukee gets its first green bike lane installed in Riverwest Updated:  8/27

» Mayfair Applebee's closes after 24 years in business 8/27

» Second design workshop for Tosa skate park is Thursday 8/26

» Former Wauwatosa priest pleads not guilty to embezzlement charges 8/26

» The social media story of Wauwatosa West at Wauwatosa East football 8/23

» Trojans rule the city another year 8/22

» Preps football photos of the week: Aug. 22 8/22

» Poll: Who will win the Battle of Wauwatosa: West or East? 8/21

» Wauwatosa students hit same average ACT score as last year 8/20

» Twirly Birds vintage and hand-craft store moves to Waukesha 8/19

» Paving complete on North Avenue 8/18

» Nicolet cancels varsity football season 8/14

» East Tosa business owners clash over BID 8/11

» Weed found at Macy's inside Mayfair mall 8/11

» Woman leaves dog in hot car, charged with animal cruelty 8/1

» Children's theater presents free performance of "The Frog Prince" tomorrow night 7/30

» Hawaiian grocery crowd-funds commercial kitchen 7/28

» Wauwatosa School District creates new mobile app 7/25

» Tosa responds to concerns about radiation from water meters 7/25

» Menomonee River 14-year-old drowning victim identified 7/21

View All Posts Got a tip? Welcome rss
Deal Watch - Milwaukee

Milwaukee's Best Discounts & Deals

Local Business Directory

CONNECT