Understanding bacteria’s resistance to antibiotics may lead to better treatments

Feb. 21, 2014

The Medical College of Wisconsin (MCW) has received a two-year $378,000 grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to study the mechanisms underlying drug resistance in bacteria.

Christopher J. Kristich, PhD, assistant professor of microbiology and molecular genetics at MCW, is principal investigator for the grant. His laboratory studies how bacteria sense environmental stimuli and how these stimuli influence cellular processes that enhance bacterial survival, growth and resistance to antibiotics.

Although the bacterium Enterococcus faecalis (E. faecalis) is found naturally in the human digestive system, it is one of the most common causes of hospital-acquired infections and is inherently resistant to a variety of antimicrobial agents and commonly prescribed antibiotics. The genetic and molecular mechanisms of drug resistance in E. faecalis are not well-understood. One aim of the project is to determine the relationship between drug resistance and cellular levels of different nucleotides, the biochemical building blocks of DNA. The overall goal of these studies is to improve understanding of the genetic basis of bacterial drug resistance.

The project may provide new strategies for preventing or treating infections caused by bacteria that are resistant to multiple antibiotics. The project is funded by NIH grant 1R21AI109198-01.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.

Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» 10-year-old girl dies after freeway crash in Dane County 11/25

» Wauwatosa unveils convenient, affordable water online water bill payment options 11/25

» Wauwatosa East girls basketball team uses big second half to beat Wisconsin Lutheran 11/25

» Plenty of positives in Wauwatosa West girls' basketball loss to Kettle Moraine 11/25

» Wauwatosa East boys basketball team could battle for GMC title 11/25

» Wauwatosa West swimming team has bright future with talented underclassmen on the rise 11/25

» MacGillis, Barkow share Wauwatosa West boys volleyball MVP honors 11/25

» Wauwatosa West boys basketball team looks for improvement 11/25

» Sports Notes: Nov. 26, 2015 11/25

» Wauwatosa East volleyball season has solid season despite just missing another trip to state 11/25

» Wauwatosa Hurricanes return three state qualifiers — Danny Larson, Cal Hartt, Avery Weishoff 11/25

» Milwaukee County Zoo celebrates first birthday of young gorilla 11/24

» Wauwatosa stores set Thanksgiving, Black Friday hours 11/23

» Tosa's city health department earns national accreditation 11/23

» Free screening of 'Most Likely to Succeed' held Dec. 1 11/23

» Wauwatosa stores launch Small Business Saturday event 11/20

» Updated state championship game rankings of area prep football teams and players 11/19

» Wauwatosa dealership taking 'extra precautions' after four vehicles were stolen Updated:  11/19

» Wauwatosa East girls basketball team has plenty of experience returning 11/18

» Wauwatosa East's Potter earns two team cross-country awards 11/18

» Wauwatosa West girls to field experienced basketball team 11/18

» Wauwatosa East's Ripple ends career with impressive showing at state swimming meet 11/18

» Wauwatosa West freshman Julia Larson does well at state swimming championships 11/17

» Wauwatosa West's Alicia Picard, Alyssa Piek, Nicole Mystrow earn top tennis honors 11/17

» Christian Laettner hoops camps at Wauwatosa East successful 11/17

View All Posts Got a tip? Welcome rss



Hidden Tosa


"Hidden Tosa" is a semi-regular feature where reporters Rory Linnane or Rachel Minske explore the closed down and closed off parts of Wauwatosa.


Local Business Directory