The Medical College of Wisconsin (MCW) has received a four-year, $1.2 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to study the way in which the human body metabolizes drugs, and the causes behind abnormal steroid hormone production.
Jung-Ja Kim, PhD, professor of biochemistry, is the primary investigator of the grant.
The cytochrome P450 family is a large group of enzymes involved in drug metabolism and steroid hormone synthesis. While much is known about the mechanism and structure of P450s, little is known about their interaction with cytochrome P450 reductase (CYPOR), the other protein responsible for these metabolic processes. Additionally, mutations of the gene responsible for producing CYPOR lead to decreased steroid production, which can cause a range of disorders, including death in utero.
In this project, Dr. Kim will seek to understand the mechanisms of interaction between P450s and CYPOR. Understanding how the body processes drugs at a molecular level will lead to development of better drugs. Furthermore, the findings will be used to design therapeutics for patients suffering from a malfunctioning of steroid hormone synthesis.
Your link to the biggest stories in the suburbs delivered Thursday mornings.
Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter Get the Newsletter!
- Sky Zone Launches Fitness Challenge
- Ramirez Family Foundation pledges $1 million to improve healthcare quality and reduce costs
- Alicia, My Story
- 29th Annual Easter Egg Hunt
- NEWCASTLE PLACE TO HOST MEMORIES IN THE MAKING® ART SHOWCASE
- Holy Week Celebration Services at Trinity UCC
- Prata Duo To Present Free Concert
- MCW researchers to study medication to treat traumatic brain injury
- Two Comedy Shows benefit local military charities
- 15 Companies Join Milwaukee/NARI Home Improvement Council