NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
43°
H 45° L 43°
Cloudy | 8MPH

Researcher to Investigate Mechanics of Drug Metabolism

Feb. 3, 2014

The Medical College of Wisconsin (MCW) has received a four-year, $1.2 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to study the way in which the human body metabolizes drugs, and the causes behind abnormal steroid hormone production.

Jung-Ja Kim, PhD, professor of biochemistry, is the primary investigator of the grant.

The cytochrome P450 family is a large group of enzymes involved in drug metabolism and steroid hormone synthesis. While much is known about the mechanism and structure of P450s, little is known about their interaction with cytochrome P450 reductase (CYPOR), the other protein responsible for these metabolic processes. Additionally, mutations of the gene responsible for producing CYPOR lead to decreased steroid production, which can cause a range of disorders, including death in utero.

In this project, Dr. Kim will seek to understand the mechanisms of interaction between P450s and CYPOR. Understanding how the body processes drugs at a molecular level will lead to development of better drugs. Furthermore, the findings will be used to design therapeutics for patients suffering from a malfunctioning of steroid hormone synthesis.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

View All Posts Got a tip? Welcome rss
Deal Watch - Milwaukee

Milwaukee's Best Discounts & Deals

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

Local Business Directory

CONNECT