The Medical College of Wisconsin (MCW) has received a four-year, $1.2 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to study the way in which the human body metabolizes drugs, and the causes behind abnormal steroid hormone production.
Jung-Ja Kim, PhD, professor of biochemistry, is the primary investigator of the grant.
The cytochrome P450 family is a large group of enzymes involved in drug metabolism and steroid hormone synthesis. While much is known about the mechanism and structure of P450s, little is known about their interaction with cytochrome P450 reductase (CYPOR), the other protein responsible for these metabolic processes. Additionally, mutations of the gene responsible for producing CYPOR lead to decreased steroid production, which can cause a range of disorders, including death in utero.
In this project, Dr. Kim will seek to understand the mechanisms of interaction between P450s and CYPOR. Understanding how the body processes drugs at a molecular level will lead to development of better drugs. Furthermore, the findings will be used to design therapeutics for patients suffering from a malfunctioning of steroid hormone synthesis.
Your link to the biggest stories in the suburbs delivered Thursday mornings.
Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter Get the Newsletter!
- Stamp Show celebrates club's 125th year
- Up and Coming Website for Teen Moms
- CTSI funds ovarian cancer research
- The "LifeStory Memoir Writer's" Workshop
- Youth Basketball events hosted by WI Shooters
- Resume and interview workshop classes in October
- Annual Candlelit Stroll Offers a Time and Place to Share, Grieve, and Celebrate Life
- 2014 Holiday Folk Fair International to Host 5k Run/Walk
- Milwaukee/NARI Offers September 17 Panel Discussion on Creating an Outdoor Living Space
- Better breathing for sleep apnea patients