NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
48°
H 63° L 41°
Clear | 0MPH

Metamorphic Protein Could Lead to New AIDS-Fighting Drugs

Jan. 2, 2014

The Medical College of Wisconsin (MCW) has received a one-year, $353,000 grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases (NIAID) to study a unique protein that shows promise as an HIV inhibitor.

Brian Volkman, PhD, professor of biochemistry at MCW, is the primary investigator of the grant.

The United Nations estimates that more than 35 million people worldwide are living with HIV, the virus which causes AIDS. There is no cure for HIV, but a variety of medications can be used to control the virus. In this project, Dr. Volkman’s team will investigate the characteristics of ‘metamorphic’ proteins, a newly discovered class of proteins which are unlike typical proteins in that they transform between two specific folded arrangements. Lymphotactin, a prototypical metamorphic protein, was recently shown to bind HIV particles and to inhibit infection of T cells. In a study published in PLoS Pathogens, http://dx.plos.org/10.1371/journal.ppat.1003852, Paolo Lusso, PhD, a scientist at NIAID, and his team at compared the antiviral activity of various lymphotactin proteins designed and produced Dr. Volkman’s lab.

Christina Guzzo, PhD, is lead author of the paper. Other co-authors at NAIAD include Yin Lin, PhD; Huiyi Miao, PhD; Raffaello Cimbro, PhD; and Anthony Fauci, PhD. MCW contributors are Dr. Volkman and Jamie Fox, PhD. The study was supported by NIH grant R01AI063325.

Because an engineered version of lymphotactin that is locked into one of the two folded arrangements lost the ability to bind or inhibit HIV, the ability to transform appears to be necessary for its biological function. The new project, supported by NIH grant R56AI103225, will fund experiments in Dr. Volkman’s lab to determine whether the metamorphic behavior of lymphotactin is important for inhibition of HIV or other human pathogens.

Once its antiviral activity is understood in the context of the metamorphic structure, lymphotactin may be developed as the lead compound in a new class of HIV-1 inhibitors with the potential to reduce the health burden of HIV/AIDS.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Vape Haven rejected by Common Council 10:05 PM

» Consideration overdue: Thievery marring Little Free Libraries 05:32 PM

» Thai-namite plans fall through in East Tosa 9/15

» Preps football photos of the week: Sept. 12 9/12

» Chili'n on the Ave. is Saturday 9/12

» DSW Designer Shoe Warehouse opens tomorrow at Mayfair Collection 9/9

» TosaFest fight had no arrests or reported injuries, police say 9/9

» E-Cigarette store Vape Haven rejected by Tosa Plan Commission 9/8

» 10 Days in Tosa starts today 9/8

» 'Chaotic' scene at TosaFest limited to one area, mayor says 9/7

» Preps football photos of the week: Sept. 5 9/7

» Unruly teens disrupt Tosa Fest Updated:  9/6

» See inside Wisconsin International Academy Saturday 9/5

» Athleta coming to Mayfair 9/2

» Preps football photos of the week: Aug. 29 8/29

» Tosa West's Purifoy, big plays spark 35-15 win 8/29

» 88-year-old passenger dies after three-car crash in Tosa 8/29

» Nordstrom at Mayfair is planning a restaurant, Ruscello, and a coffee bar 8/29

» Police say train accident was 'apparent suicide' by Oak Creek man 8/28

» Milwaukee gets its first green bike lane installed in Riverwest Updated:  8/27

» Mayfair Applebee's closes after 24 years in business 8/27

» Second design workshop for Tosa skate park is Thursday 8/26

» Former Wauwatosa priest pleads not guilty to embezzlement charges 8/26

» The social media story of Wauwatosa West at Wauwatosa East football 8/23

» Trojans rule the city another year 8/22

View All Posts Got a tip? Welcome rss
Deal Watch - Milwaukee

Milwaukee's Best Discounts & Deals

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

Local Business Directory

CONNECT