NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
43°
H 45° L 34°
Clear | 9MPH

Metamorphic Protein Could Lead to New AIDS-Fighting Drugs

Jan. 2, 2014

The Medical College of Wisconsin (MCW) has received a one-year, $353,000 grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases (NIAID) to study a unique protein that shows promise as an HIV inhibitor.

Brian Volkman, PhD, professor of biochemistry at MCW, is the primary investigator of the grant.

The United Nations estimates that more than 35 million people worldwide are living with HIV, the virus which causes AIDS. There is no cure for HIV, but a variety of medications can be used to control the virus. In this project, Dr. Volkman’s team will investigate the characteristics of ‘metamorphic’ proteins, a newly discovered class of proteins which are unlike typical proteins in that they transform between two specific folded arrangements. Lymphotactin, a prototypical metamorphic protein, was recently shown to bind HIV particles and to inhibit infection of T cells. In a study published in PLoS Pathogens, http://dx.plos.org/10.1371/journal.ppat.1003852, Paolo Lusso, PhD, a scientist at NIAID, and his team at compared the antiviral activity of various lymphotactin proteins designed and produced Dr. Volkman’s lab.

Christina Guzzo, PhD, is lead author of the paper. Other co-authors at NAIAD include Yin Lin, PhD; Huiyi Miao, PhD; Raffaello Cimbro, PhD; and Anthony Fauci, PhD. MCW contributors are Dr. Volkman and Jamie Fox, PhD. The study was supported by NIH grant R01AI063325.

Because an engineered version of lymphotactin that is locked into one of the two folded arrangements lost the ability to bind or inhibit HIV, the ability to transform appears to be necessary for its biological function. The new project, supported by NIH grant R56AI103225, will fund experiments in Dr. Volkman’s lab to determine whether the metamorphic behavior of lymphotactin is important for inhibition of HIV or other human pathogens.

Once its antiviral activity is understood in the context of the metamorphic structure, lymphotactin may be developed as the lead compound in a new class of HIV-1 inhibitors with the potential to reduce the health burden of HIV/AIDS.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Ask NOW: When will the lanes on Burleigh Street near Highway 45 be less confusing? 4/15

» In helping others, Bachman became 'Mr. Wauwatosa' 4/12

» City says goodbye to 'Mr. Wauwatosa' 4/9

» Three new Bartolotta restaurants announced for Mayfair Collection 4/8

» Vukmir releases records related to ALEC work 4/4

» Voters disagree with Citizens United ruling 4/2

» Brian Bawden elected to Wauwatosa School Board 4/1

» Jason Kofroth elected District 7 alderman 4/1

» Michael Walsh elected District 4 alderman 4/1

» Matt Stippich wins District 1 aldermanic seat 4/1

» Body found in Tosa identified as James Kieckbusch, 57 4/1

» Body found at border of Elm Grove and Wauwatosa Updated:  4/1

» Michael Lovell's move is a net gain for Milwaukee, business leaders say 3/26

» Wauwatosa police seek suspect in BMO Harris Bank robbery 3/14

» Firm in line for $7.2 million MMSD contract didn't show qualifications Updated:  3/11

» West advances with 75-4 win over James Madison 3/4

» Milwaukeeans share paczki on social media 3/4

» Whitefish Bay finds its tempo, downs Tosa East 2/28

» Messmer rallies to beat Tosa West 2/28

» East's Wheeler's free throws lead to upset of Shorewood 2/25

» Wauwatosa West 'We the People' team making another run in national competition 2/25

» Menomonee River Parkway segment closed to through traffic 2/24

» Salmon's 31 sparks Raiders past Spartans, 50-34 2/21

» Jury fails to reach verdict in firearm silencer case for gun collector 2/20

» Lawyer testifies why he bought silencer during reverse sting Updated:  2/20

View All Posts Got a tip? Welcome rss
Deal Watch - Milwaukee

Milwaukee's Best Discounts & Deals

Local Business Directory

CONNECT