Graduate Student’s Diabetes Research Earns Federal Funding

Nov. 7, 2013

The Medical College of Wisconsin (MCW) has received a six-year, $266,000 grant from the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases to study the science of diabetes at a cellular level.

Megan Determan, a third year graduate student in the department of cell biology, neurobiology, and anatomy, is the primary investigator of the grant. Determan is enrolled in MCW’s Medical Scientist Training Program, which combines curricula of medical school and graduate school.

According to the Centers for Disease Control, one in ten Americans has diabetes, and that number is expected to double or triple by 2050. Diabetes is the leading cause of kidney failure and blindness in older adults, and the disease doubles the risk of heart attack and stroke. The cellular mechanisms causing diabetes are not well understood.

In this project, Determan will study the most prevalent form of monogenic diabetes (diabetes caused by a mutation in one gene), which is called HNF1A-MODY. In that specific type of diabetes, only one copy of the HNF1A gene is functional.

Using stem cells induced from skin samples obtained from adults with the disease, and stem cells induced from healthy adults, the research team will create hepatocytes (liver cells) and identify changes in gene transcription in the mutant cells. Determan will also generate pancreatic beta cells, some from diabetic patients, and others from healthy patients, to evaluate glucose-response and insulin secretion.

The results should establish which molecular mechanisms are altered in the liver and pancreas cells in patients with monogenic diabetes caused by the HNF1A mutation and characterize the phenotype of these cells.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.

Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» 10-year-old girl dies after freeway crash in Dane County 11/25

» Wauwatosa unveils convenient, affordable water online water bill payment options 11/25

» Wauwatosa East girls basketball team uses big second half to beat Wisconsin Lutheran 11/25

» Plenty of positives in Wauwatosa West girls' basketball loss to Kettle Moraine 11/25

» Wauwatosa East boys basketball team could battle for GMC title 11/25

» Wauwatosa West swimming team has bright future with talented underclassmen on the rise 11/25

» MacGillis, Barkow share Wauwatosa West boys volleyball MVP honors 11/25

» Wauwatosa West boys basketball team looks for improvement 11/25

» Sports Notes: Nov. 26, 2015 11/25

» Wauwatosa East volleyball season has solid season despite just missing another trip to state 11/25

» Wauwatosa Hurricanes return three state qualifiers — Danny Larson, Cal Hartt, Avery Weishoff 11/25

» Milwaukee County Zoo celebrates first birthday of young gorilla 11/24

» Wauwatosa stores set Thanksgiving, Black Friday hours 11/23

» Tosa's city health department earns national accreditation 11/23

» Free screening of 'Most Likely to Succeed' held Dec. 1 11/23

» Wauwatosa stores launch Small Business Saturday event 11/20

» Updated state championship game rankings of area prep football teams and players 11/19

» Wauwatosa dealership taking 'extra precautions' after four vehicles were stolen Updated:  11/19

» Wauwatosa East girls basketball team has plenty of experience returning 11/18

» Wauwatosa East's Potter earns two team cross-country awards 11/18

» Wauwatosa West girls to field experienced basketball team 11/18

» Wauwatosa East's Ripple ends career with impressive showing at state swimming meet 11/18

» Wauwatosa West freshman Julia Larson does well at state swimming championships 11/17

» Wauwatosa West's Alicia Picard, Alyssa Piek, Nicole Mystrow earn top tennis honors 11/17

» Christian Laettner hoops camps at Wauwatosa East successful 11/17

View All Posts Got a tip? Welcome rss



Hidden Tosa


"Hidden Tosa" is a semi-regular feature where reporters Rory Linnane or Rachel Minske explore the closed down and closed off parts of Wauwatosa.


Local Business Directory