NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
27°
H 27° L 14°
Clear | 0MPH

Researcher to Study Causes of Kidney Disease

Oct. 27, 2013

The Medical College of Wisconsin (MCW) has received a four-year, $1.3 million grant from the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases to study actions of protein called endothelin-1 (ET-1) in the progression of glomerular kidney diseases.

Andrey Sorokin, PhD, professor of medicine (nephrology) at MCW, is the primary investigator of the grant.

Dr. Sorokin will study the molecular causes of glomerulosclerosis, which occurs when the mesangial cells (located around the tiny blood vessels inside the glomerulus) are not functioning normally. Earlier work by Dr. Sorokin’s team identified a novel signaling pathway regulated by ET-1, the protein which plays an essential role in this type of kidney disease. When ET-1 production increases, the mesangial cells become dysfunctional, causing decrease in renal function, and, often, kidney failure.

In this project, Dr. Sorokin’s team will study the signaling pathways that lead to the dysfunction of mesangial cells using unique genetically engineered rat strains.

Understanding the mechanisms of ET-1 induced renal diseases will broaden our overall understanding of kidney function; this study will provide valuable information that could lead to development of potential therapeutic targets.

This project is supported by the National Institutes of Health under award number: 1R01DK098159-01A1.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Wauwatiki plans to bring Caribbean cuisine, cocktails to East Tosa 3/27

» Student writing contest entries due today 3/27

» Zoo Interchange ramp closing March 26-April 2 3/26

» Wauwatosa police chase ends in crash, injury 3/24

» The Sprint Episode Three: WIAA state basketball tournament retrospective 3/23

» Car fire extinguished at Colectivo in Wauwatosa 3/23

» Top of truck 'peeled back like a can' after collision with bridge in Wauwatosa 3/20

» Wauwatosa mayor, superintendent schedule town hall meetings 3/19

» Architecture firm to replace Caribbean Tan in Wauwatosa 3/19

» Cafe Bavaria in Wauwatosa told to shut down patio fire 3/18

» More than $7,000 in merchandise stolen from Verizon Wireless on Mayfair Road 3/17

» The Sprint Episode Two: local teams look to defend state basketball titles this week 3/16

» Authentic Birth Center celebrates 100th childbirth 3/16

» Tosa East not going to state after 41-40 loss to Greendale in sectional final 3/14

» Green's 3-point buzzer beater helps Tosa East beat Whitefish Bay, 45-43 3/12

» Nordstrom announces opening gala for Wauwatosa store 3/11

» National Weather Service to provide storm-spotting training for Wauwatosa residents 3/11

» Venturis plan to reopen deli at Arcade building in Wauwatosa 3/10

» Two Zoo Interchange ramps closed for several months 3/9

» Tosa East beats West, 56-54, to advance to sectionals against Whitefish Bay on Thursday 3/7

» Tosa East's defense shines in upset of defending state champion Vikings 3/6

» Anthony Nash of Wauwatosa East wins EFW T-shirt design contest 3/6

» Tosa Skatepark seeks graphic designer for firefly image 3/6

» Menomonee River Parkway temporarily closed for excavation 3/5

» Fundraiser covers funeral expenses for victim of Wauwatosa house fire 3/5

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

2015 Writing Contest

 

(Click image for details)


Local Business Directory

CONNECT