The Medical College of Wisconsin (MCW) has received a four-year, $1.3 million grant from the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases to study actions of protein called endothelin-1 (ET-1) in the progression of glomerular kidney diseases.
Andrey Sorokin, PhD, professor of medicine (nephrology) at MCW, is the primary investigator of the grant.
Dr. Sorokin will study the molecular causes of glomerulosclerosis, which occurs when the mesangial cells (located around the tiny blood vessels inside the glomerulus) are not functioning normally. Earlier work by Dr. Sorokin’s team identified a novel signaling pathway regulated by ET-1, the protein which plays an essential role in this type of kidney disease. When ET-1 production increases, the mesangial cells become dysfunctional, causing decrease in renal function, and, often, kidney failure.
In this project, Dr. Sorokin’s team will study the signaling pathways that lead to the dysfunction of mesangial cells using unique genetically engineered rat strains.
Understanding the mechanisms of ET-1 induced renal diseases will broaden our overall understanding of kidney function; this study will provide valuable information that could lead to development of potential therapeutic targets.
This project is supported by the National Institutes of Health under award number: 1R01DK098159-01A1.
Your link to the biggest stories in the suburbs delivered Thursday mornings.
Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter Get the Newsletter!
- Stamp Show celebrates club's 125th year
- Up and Coming Website for Teen Moms
- CTSI funds ovarian cancer research
- The "LifeStory Memoir Writer's" Workshop
- Youth Basketball events hosted by WI Shooters
- Resume and interview workshop classes in October
- Annual Candlelit Stroll Offers a Time and Place to Share, Grieve, and Celebrate Life
- 2014 Holiday Folk Fair International to Host 5k Run/Walk
- Milwaukee/NARI Offers September 17 Panel Discussion on Creating an Outdoor Living Space
- Better breathing for sleep apnea patients