The Medical College of Wisconsin (MCW) has received a four-year, $1.5 million grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to study lymphocytes, the body’s “natural killer” cells, and determine the signaling pathways that elicit disease-fighting responses at a cellular level in the body.
Subramaniam Malarkannan, PhD, associate professor of medicine in the division of hematology and oncology, and an investigator at the Blood Research Institute, BloodCenter of Wisconsin, is the primary investigator of the grant.
The organization of signaling events in lymphocytes is not well understood. Hundreds of signaling molecules “share” information that results in cellular functions, but the precise mechanisms that coordinate that response remain an enigma.
Scaffolding proteins, which are crucial regulators of signaling pathways, provide part of the explanation. In this research project, Dr. Malarkannan will explore the role of a specific scaffolding protein called IQGAP1, which is hypothesized to function as a processing center, controlling multiple signaling pathways.
The ultimate goal of Dr. Malarkannan’s laboratory research is to specifically augment the cytotoxic potentials of human lymphocyte cells and utilize that potential to eliminate cancerous tumors in patients.
Your link to the biggest stories in the suburbs delivered Thursday mornings.
Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter Get the Newsletter!
- Concordia University to host community thought leaders series
- Callen Earns Esteemed 2015 Angie’s List Super Service Award
- CigarMKE - Know Your Leaf
- R.A. Smith National’s Mike Bach Promoted to Project Manager
- White House of Music Launches Non-Profit Foundation
- MCW researchers discover ancient cellular mutation leading to multi-celled organisms
- Break Out of the Winter Blues – and Heat Things Up – at Valentine’s Day!
- IndependenceFirst Stride & Glide 5K and family-friendly fitness event
- Callen Receives 2015 Pulse of the City Customer Service Award
- MCW to host renowned nutrition expert at heart health conference