MCW Researcher to Study Causes of Pain in Sickle Cell Disease

Oct. 2, 2013

The Medical College of Wisconsin (MCW) and the Children’s Hospital of Wisconsin (CHW) Research Institute have received a five-year, $696,000 grant from the National Institutes of Health’s National Heart, Lung and Blood Institute (1K23HL114636-01A1) to study the mechanisms of pain in sickle cell disease.

Amanda Brandow, D.O., M.S, assistant professor of pediatric hematology and oncology at MCW and an investigator at the CHW Research Institute, is the primary investigator of the grant.

Sickle cell disease is a group of genetic disorders that affect hemoglobin, which is the molecule in red blood cells that delivers oxygen to the body. Patients with sickle cell disease have episodes of severe acute pain that require repeated emergency department visits and hospitalizations for intravenous narcotics to treat the pain. Patients with sickle cell disease also suffer from chronic debilitating pain that is often managed at home with oral narcotics. Novel therapies are needed to treat or prevent sickle cell disease pain.

Despite pain being the most common complication of sickle cell disease, the mechanisms of sickle cell disease pain are not well understood which impedes ability to develop novel treatments or preventative measures. With this grant, Dr. Brandow will investigate the underlying neurobiology of sickle cell disease pain by focusing on changes in the peripheral nervous system and whether damage to those nerves may result in a type of pain called neuropathic pain. Dr. Brandow and her research team will also explore whether ongoing inflammation is a contributor to neuropathic pain in these patients.

Results of this proposal have the potential to provide a guide for further studies into the neurobiology of sickle cell pain and ultimately may contribute to the discovery of novel targets for therapeutics to prevent or treat sickle cell disease pain and relieve the suffering these patients experience.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Changes coming to Wauwatosa Village: The Flower Lady finds new home 2/11

» Bryant & Stratton College offers new nursing program at Tosa campus 2/11

» Video: Tosa Top 5: Five things you need to know in Wauwatosa this week Updated:  2/11

» KFC in Wauwatosa robbed Wednesday morning, suspect still unknown 2/11

» What residents in Southeast Wisconsin need to know to prevent the spread of Zika virus Updated:  2/11

» For Wauwatosa Hurricanes' Danny Larson, it's all about the team 2/10

» Wauwatosa West boys basketball team bounces back to beat New Berlin West 2/10

» Wauwatosa West girls basketball team drops five in a row 2/10

» Wauwatosa East girls basketball team defeats Menomonee Falls to snap 3-game losing streak 2/10

» Big Cheese Classic National Wheelchair Basketball tourney set for Feb. 20-21 2/10

» Wauwatosa's Larson wins two swimming championship 2/10

» Wauwatosa East boys basketball team drops third straight game 2/10

» Five Wauwatosa East student-athletes to play at collegiate level 2/10

» Wauwatosa's Beekman to play football at Southern A&M 2/10

» Tosa officers return to work following police-involved shooting 2/9

» Fat Tuesday: How Wauwatosa celebrated 2/9

» As trial begins, man pleads guilty to shooting Wauwatosa police officer Updated:  2/8

» Tosa's All-City Read well underway, more events to come 2/8

» Wauwatosa Revolving Loan Fund celebrates 25 years 2/8

» Milwaukee Co. Zoo welcomes two new lionesses 2/8

» Updated rankings of area prep boys and girls basketball teams and players 2/8

» Wauwatosa West boys basketball team defeats Shorewood, South Milwaukee 2/3

» Marquette gets revenge with 75-55 victory over Wauwatosa East boys 2/3

» Wauwatosa East's Stewart, Green combine for 49 points in win over Brookfield Central 2/3

» Wauwatosa West girls basketball team loses road games to Shorewood, South Milwaukee 2/3

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporters Rory Linnane or Rachel Minske explore the closed down and closed off parts of Wauwatosa.

Advertisement

Election center 2016

Election overage from from the MyCommunityNow coverage area covering suburban Milwaukee County and the eastern half of Waukesha County.

Suburban Milwaukee election center 2016

Local Business Directory

CONNECT