MCW Researcher to Study Causes of Pain in Sickle Cell Disease

Oct. 2, 2013

The Medical College of Wisconsin (MCW) and the Children’s Hospital of Wisconsin (CHW) Research Institute have received a five-year, $696,000 grant from the National Institutes of Health’s National Heart, Lung and Blood Institute (1K23HL114636-01A1) to study the mechanisms of pain in sickle cell disease.

Amanda Brandow, D.O., M.S, assistant professor of pediatric hematology and oncology at MCW and an investigator at the CHW Research Institute, is the primary investigator of the grant.

Sickle cell disease is a group of genetic disorders that affect hemoglobin, which is the molecule in red blood cells that delivers oxygen to the body. Patients with sickle cell disease have episodes of severe acute pain that require repeated emergency department visits and hospitalizations for intravenous narcotics to treat the pain. Patients with sickle cell disease also suffer from chronic debilitating pain that is often managed at home with oral narcotics. Novel therapies are needed to treat or prevent sickle cell disease pain.

Despite pain being the most common complication of sickle cell disease, the mechanisms of sickle cell disease pain are not well understood which impedes ability to develop novel treatments or preventative measures. With this grant, Dr. Brandow will investigate the underlying neurobiology of sickle cell disease pain by focusing on changes in the peripheral nervous system and whether damage to those nerves may result in a type of pain called neuropathic pain. Dr. Brandow and her research team will also explore whether ongoing inflammation is a contributor to neuropathic pain in these patients.

Results of this proposal have the potential to provide a guide for further studies into the neurobiology of sickle cell pain and ultimately may contribute to the discovery of novel targets for therapeutics to prevent or treat sickle cell disease pain and relieve the suffering these patients experience.

Community Watch

» Tosa man with gun trove to plead guilty of illegal dealing 03:16 PM

» Wauwatosa endorses bus rapid transit route, more approvals needed Updated:  6/23

» Video: Tosa Top 5: Five things you need to know about in Wauwatosa this week 6/23

» Wauwatosa officer fatally shoots man at Madison Park 6/23

» Wauwatosa Public Library announces list of summer events 6/22

» Blood drives scheduled for Milwaukee County during month of July 6/22

» Two lanes on Wauwatosa's Harmonee Bridge to close Thursday 6/22

» Milwaukee Co. Zoo welcomes baby harbor seal, bonobo 6/22

» Teens accused of trying to rob Tosa resident with BB gun Updated:  6/22

» Hidden Tosa: Inside the Wauwatosa Police Department 6/22

» Offense holding back Wauwatosa West baseball team 6/21

» Wauwatosa East baseball wins four conference games 6/21

» Former Wauwatosa West star Austin Jones drafted by Chicago Cubs in 26th round 6/21

» East Tosa Gran Prix returns to Wauwatosa June 26 6/21

» Wauwatosa School Board votes to give teachers a bump in pay Updated:  6/20

» New records for Tosa Swim Club 6/20

» Tosa customers temporarily lose power after squirrel causes blown fuse 6/20

» Video: VISIT Milwaukee, city of Wauwatosa launch new tourism video 6/20

» Mayfair mall's Sephora draws police attention since February Updated:  6/17

» Pool at Hoyt Park running again following mid-week mechanical failure 6/17

» Wauwatosa seeks participants for survey on city communication 6/17

» Tosa Top 5: Five things you need to know about in Wauwatosa this week 6/16

» Initial Reaction Podcast: MLB Draft's Wisconsin flavor and WIAA's postseason model Updated:  6/15

» Help make memorial signs for Orlando victims at Tosa's CraftSpot 6/15

» Wauwatosa West baseball team drops four in a row 6/15

View All Posts Got a tip? Welcome rss

Best Summer Ever

 

We've made it easy for you to get out and go this summer. From hitting the trails for a bike ride or walk, to where to find beer gardens in the area, to the best places to swim in Waukesha County to the best summer drinks and summer reads, check out our 2016 summer guide.

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where our Wauwatosa reporter explores the closed down and closed off parts of Wauwatosa.

Advertisement

CONNECT