NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
84°
H 84° L 61°
Partly Cloudy | 5MPH

MCW Researcher to Study Causes of Pain in Sickle Cell Disease

Oct. 2, 2013

The Medical College of Wisconsin (MCW) and the Children’s Hospital of Wisconsin (CHW) Research Institute have received a five-year, $696,000 grant from the National Institutes of Health’s National Heart, Lung and Blood Institute (1K23HL114636-01A1) to study the mechanisms of pain in sickle cell disease.

Amanda Brandow, D.O., M.S, assistant professor of pediatric hematology and oncology at MCW and an investigator at the CHW Research Institute, is the primary investigator of the grant.

Sickle cell disease is a group of genetic disorders that affect hemoglobin, which is the molecule in red blood cells that delivers oxygen to the body. Patients with sickle cell disease have episodes of severe acute pain that require repeated emergency department visits and hospitalizations for intravenous narcotics to treat the pain. Patients with sickle cell disease also suffer from chronic debilitating pain that is often managed at home with oral narcotics. Novel therapies are needed to treat or prevent sickle cell disease pain.

Despite pain being the most common complication of sickle cell disease, the mechanisms of sickle cell disease pain are not well understood which impedes ability to develop novel treatments or preventative measures. With this grant, Dr. Brandow will investigate the underlying neurobiology of sickle cell disease pain by focusing on changes in the peripheral nervous system and whether damage to those nerves may result in a type of pain called neuropathic pain. Dr. Brandow and her research team will also explore whether ongoing inflammation is a contributor to neuropathic pain in these patients.

Results of this proposal have the potential to provide a guide for further studies into the neurobiology of sickle cell pain and ultimately may contribute to the discovery of novel targets for therapeutics to prevent or treat sickle cell disease pain and relieve the suffering these patients experience.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Woman leaves dog in hot car, charged with animal cruelty 12:06 PM

» Children's theater presents free performance of "The Frog Prince" tomorrow night 7/30

» Hawaiian grocery crowd-funds commercial kitchen 7/28

» Wauwatosa School District creates new mobile app 7/25

» Tosa responds to concerns about radiation from water meters 7/25

» Menomonee River 14-year-old drowning victim identified 7/21

» Boy drowns in the Menomonee River at Hoyt Park Updated:  7/19

» Former priest accused of theft again fails to appear in court 7/14

» Police connect teens to recent Milwaukee, Wauwatosa carjackings 7/12

» Briggs & Stratton closing Georgia site, will add 370 jobs in Wauwatosa Updated:  7/10

» Section of I-94 to close entirely July 18-21 7/10

» Wauwatosa man killed in crash that snarled Highway 41 traffic 7/10

» Hundreds in Tosa without power 7/1

» Wauwatosa detective sentenced for drug theft 6/24

» Milwaukee suburbs Fourth of July 2014 celebrations 6/20

» Social media photos of the June 18 storms around Southeast Wisconsin 6/18

» Sewage backups may occur with Wauwatosa sewer at full capacity 6/18

» Corner Bakery coming to Mayfair Collection in Wauwatosa 6/11

» Gunfire leads to police chase in Milwaukee, Wauwatosa 6/11

» Wauwatosa Catholic authorized to become International Baccalaureate World School 6/4

» Waukesha YMCA plans to purchase Wauwatosa site 6/4

» New Milwaukee Bucks owners visit Cranky Al's in Wauwatosa 5/29

» Picnic Basket sandwich shop opens in Wauwatosa 5/22

» State to spend $13.5 million on transit to settle Zoo Interchange suit 5/19

» Gem, mineral and fossil show coming this weekend 5/16

View All Posts Got a tip? Welcome rss
Deal Watch - Milwaukee

Milwaukee's Best Discounts & Deals

Local Business Directory

CONNECT