NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
68°
H 81° L 59°
Clear | 3MPH

Antioxidants, Stress and Hypertension: Researchers Seek Answers to Fundamental Questions

Sept. 27, 2013

The Medical College of Wisconsin (MCW) has received a five-year, $9.5 million grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to study the role of hydrogen peroxide in development of salt-sensitive hypertension.

Allen Cowley, PhD, professor and chair of physiology at MCW, is the primary investigator of the program project grant. Co-primary investigators are David Mattson, PhD, professor of physiology; and Mingyu Liang, PhD, MB, professor of physiology. Dr. Cowley holds the James J. Smith & Catherine Welsch Smith Chair in Physiology, and Harry & Gertrude Hack Term Chair in Physiology, at MCW.

Nearly one out of three American adults has hypertension, or high blood pressure (78 million). It is the primary cause of death for 62,000 people in the U.S. every year, and a contributing factor in more than 348,000 deaths. Many of the mechanisms contributing to hypertension are still unknown; however, in 30-50% of people, ingestion of salt contributes to a rise in blood pressure.

The unifying hypothesis of this program project grant centers on the concept that hydrogen peroxide production in the part of the kidney called the renal outer medulla plays a dominant role in the development of salt-sensitive hypertension.

In the first project, Dr. Cowley’s team will explore the hypothesis that increased salt intake results in excess production of hydrogen peroxide, which constricts the blood vessels of the kidney. Dr. Mattson’s team suspects that constriction leads to an initial increase in arterial pressure, which results in an increase of free radicals and cytokines in the kidney. Finally, Dr. Liang’s team will evaluate the hypothesis that a newly discovered pathway of hydrogen peroxide production related to metabolism contributes importantly to the development of hypertension.

The conceptually unique, yet correlated hypotheses will advance understanding of the molecular and physiological mechanisms underlying salt-sensitive hypertension. Additionally, the studies will provide a better understanding of the mechanisms responsible for increased oxidative stress and enable the targeting of enzymes responsible for its generation, which should lead to better antioxidant therapies.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Milwaukee man charged for causing fatal rollover crash in Wauwatosa 11:50 AM

» Run Tosa Run raises $3K for Ronald McDonald House 5/26

» Longfellow hosting Wauwatosa's Memorial Day ceremony Monday 5/21

» Choice school, dry cleaning issues held for more discussion in Wauwatosa 5/20

» Parents rally after lawmakers expand vouchers 5/20

» Wauwatosa approves conceptual design for pocket park on North Avenue Updated:  5/20

» Wauwatosa hotel site sells for $925,000 5/20

» Tosa Tonight releases lineup for summer concert series 5/19

» Wauwatosa School Board approves raises for teachers, administrators and staff 5/19

» Wauwatosa Avenue lane to close over Memorial Day weekend 5/18

» Residents invited to help redesign streets, parks in Wauwatosa Village 5/15

» Wauwatosa alderman pulls proposal to shrink common council 5/15

» Police arrest teens for prowling after foot chase through Wauwatosa Updated:  5/14

» Initial Reaction Podcast: Massive overhaul of area conferences could be afoot 5/13

» Beer garden at Hoyt Park in Tosa reopens Wednesday, may go indoors too 5/12

» Winter's not through with us yet 5/12

» Wauwatosa mayor named to MMSD governing commission 5/11

» Police say motorcyclist riding without helmet injured in Wauwatosa collision 5/7

» Ex-Wauwatosa school board vice president 'disheartened by political dissonance' in community Updated:  5/6

» Wauwatosa celebrating Bike to School Day Wednesday 5/5

» Wauwatosa alderman proposes cutting four seats on Common Council 5/4

» East kickers blank Tosa West, 2-0 5/2

» Investigation: Family behind collapsed Falls building has a history of neglecting properties Updated:  5/1

» Wauwatosa's Lady in Red reopens as Nikki's Boutique after remodel 4/30

» Exactly 175 years ago, Wauwatosa became a town 4/30

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

2015 Writing Contest

 

(Click image for details)

Local Business Directory

CONNECT