NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
63°
H ° L °
Partly Cloudy | 12MPH

Antioxidants, Stress and Hypertension: Researchers Seek Answers to Fundamental Questions

Sept. 27, 2013

The Medical College of Wisconsin (MCW) has received a five-year, $9.5 million grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to study the role of hydrogen peroxide in development of salt-sensitive hypertension.

Allen Cowley, PhD, professor and chair of physiology at MCW, is the primary investigator of the program project grant. Co-primary investigators are David Mattson, PhD, professor of physiology; and Mingyu Liang, PhD, MB, professor of physiology. Dr. Cowley holds the James J. Smith & Catherine Welsch Smith Chair in Physiology, and Harry & Gertrude Hack Term Chair in Physiology, at MCW.

Nearly one out of three American adults has hypertension, or high blood pressure (78 million). It is the primary cause of death for 62,000 people in the U.S. every year, and a contributing factor in more than 348,000 deaths. Many of the mechanisms contributing to hypertension are still unknown; however, in 30-50% of people, ingestion of salt contributes to a rise in blood pressure.

The unifying hypothesis of this program project grant centers on the concept that hydrogen peroxide production in the part of the kidney called the renal outer medulla plays a dominant role in the development of salt-sensitive hypertension.

In the first project, Dr. Cowley’s team will explore the hypothesis that increased salt intake results in excess production of hydrogen peroxide, which constricts the blood vessels of the kidney. Dr. Mattson’s team suspects that constriction leads to an initial increase in arterial pressure, which results in an increase of free radicals and cytokines in the kidney. Finally, Dr. Liang’s team will evaluate the hypothesis that a newly discovered pathway of hydrogen peroxide production related to metabolism contributes importantly to the development of hypertension.

The conceptually unique, yet correlated hypotheses will advance understanding of the molecular and physiological mechanisms underlying salt-sensitive hypertension. Additionally, the studies will provide a better understanding of the mechanisms responsible for increased oxidative stress and enable the targeting of enzymes responsible for its generation, which should lead to better antioxidant therapies.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Menomonee River 14-year-old drowning victim identified 7/21

» Boy drowns in the Menomonee River at Hoyt Park Updated:  7/19

» Former priest accused of theft again fails to appear in court 7/14

» Police connect teens to recent Milwaukee, Wauwatosa carjackings 7/12

» Briggs & Stratton closing Georgia site, will add 370 jobs in Wauwatosa Updated:  7/10

» Section of I-94 to close entirely July 18-21 7/10

» Wauwatosa man killed in crash that snarled Highway 41 traffic 7/10

» Hundreds in Tosa without power 7/1

» Wauwatosa detective sentenced for drug theft 6/24

» Milwaukee suburbs Fourth of July 2014 celebrations 6/20

» Social media photos of the June 18 storms around Southeast Wisconsin 6/18

» Sewage backups may occur with Wauwatosa sewer at full capacity 6/18

» Corner Bakery coming to Mayfair Collection in Wauwatosa 6/11

» Gunfire leads to police chase in Milwaukee, Wauwatosa 6/11

» Wauwatosa Catholic authorized to become International Baccalaureate World School 6/4

» Waukesha YMCA plans to purchase Wauwatosa site 6/4

» New Milwaukee Bucks owners visit Cranky Al's in Wauwatosa 5/29

» Picnic Basket sandwich shop opens in Wauwatosa 5/22

» State to spend $13.5 million on transit to settle Zoo Interchange suit 5/19

» Gem, mineral and fossil show coming this weekend 5/16

» Malt Shoppe plans to focus on beer, fill growlers in Wauwatosa 5/6

» Mayfair mall gets ready for Nordstrom 5/6

» Thai-namite restaurant looks to move to East Tosa 5/2

» Our Redeemer Lutheran School named 20th best middle school in America 5/1

» Train horns heard in Wauwatosa again 5/1

View All Posts Got a tip? Welcome rss
Deal Watch - Milwaukee

Milwaukee's Best Discounts & Deals

Local Business Directory

CONNECT