The Concussed Brain at Work: fMRI Study Documents Brain Activation During Concussion Recovery
For the first time, researchers have documented irregular brain activity within the first 24 hours of a concussive injury, as well as an increased level of brain activity weeks later—suggesting that the brain may compensate for the injury during the recovery time.
The findings are published in the September issue of the Journal of the International Neuropsychological Society http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8952254.
Thomas Hammeke, PhD, professor of psychiatry and behavioral medicine at the Medical College of Wisconsin, is the lead author. Collaborators at the Cleveland Clinic; St. Mary’s Hospital in Enid, Okl.; the University of North Carolina; Franklin College in Franklin, Ind., and the Marshfield Clinic in Marshfield, Wis., co-authored the paper.
To study the natural recovery from sports concussion, 12 concussed high school football athletes and 12 uninjured teammates were evaluated at 13 hours and again at seven weeks following concussive injury.
The concussed athletes showed the expected postconcussive symptoms, including decreased reaction time and lowered cognitive abilities. Imaging via fMRI (functional magnetic resonance imaging) showed decreased activity in select regions of the right hemisphere of the brain, which suggests the poor cognitive performance of concussion patients is related to that underactivation of attentional brain circuits.
Seven weeks post-injury, the concussed athletes showed improvement of cognitive abilities and normal reaction time. However, imaging at that time showed the post-concussed athletes had more activation in the brain’s attentional circuits than did the control athletes.
“This hyperactivation may represent a compensatory brain response that mediates recovery,” said Dr. Hammeke. “This is the first study to demonstrate that reversal in activation patterns, and that reversal matches the progression of symptoms from the time of the injury through clinical recovery.”
“Deciding when a concussed player should return to the playing field is currently an inexact science,” said Dr. Stephen Rao, director of the Schey Center for Cognitive Neuroimaging at the Cleveland Clinic and a senior author. “Measuring changes in brain activity during the acute recovery period can provide a scientific basis for making this critical decision.”
Each year, an estimated 3.8 million people sustain a traumatic brain injury (TBI). TBI is a contributing factor to a third of all injury-related deaths in the United States. More than three-quarters of the TBI’s that occur are concussions or other forms of mild TBI, many of which may go undiagnosed.
Your link to the biggest stories in the suburbs delivered Thursday mornings.
Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter Get the Newsletter!
- Adolescent patients needed for study on pain
- Care and quality of life for older, rural HIV-positive adults
- HGTV’s House Hunters Returns to Southeastern Wisconsin to Feature Flat Rate Home Services’ Employee
- International Expert Dr. Michele Borba to Speak at Alverno College Character Education Conference
- Stars and Stripes Honor Flight-The Final Thank You
- Meijer Announces Opening Dates for First Wisconsin Supercenters
- Comprehensive Eye Exams Can Help Re-engage Patients Into Care for Certain Chronic Conditions, With the Potential to Help Improve Health and Reduce Costs
- Tosa East Junior Achieves Eagle Scout Award
- G.A.P.C. Hosts Annual Strawberry Fest June 14th
- Milwaukee to Host 2015 USA Ultimate Division 1 College Championships, May 22-25 at Uihlein Park