Medical College researcher to study immune cell role in hypertension and kidney disease
The Medical College of Wisconsin received a five-year, $1.7 million grant from the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases to fund an investigation of the role of immune cells in the development of hypertension and kidney disease.
David L. Mattson, Ph.D., professor of physiology, is the principal investigator for the grant.
Approximately one-third of adult Americans have hypertension, or high blood pressure, which is a major risk factor for heart and kidney disease. High blood pressure makes it more difficult for the heart to pump blood. The heart works harder to compensate, which can cause injury to blood vessels throughout the body, including those within the kidney. According to the National Institute of Diabetes and Digestive and Kidney Diseases, high blood pressure causes 25,000 new cases of kidney failure annually in the United States.
Dr. Mattson’s study is following up on data suggesting that infiltration of immune cells into the kidney contributes to the development of high blood pressure and kidney disease. It is not known, however, which specific immune cell types play a role and the mechanisms that lead to disease. This research will examine a gene, CD247, which may be involved in the infiltration and activation of immune cells within the kidney. Dr. Mattson will also look at the substances that immune cells release into the kidney to understand how they may contribute to high blood pressure and damage in the kidney.
This project will advance knowledge and may help create new therapies for patients with hypertension and kidney disease.
Your link to the biggest stories in the suburbs delivered Thursday mornings.
Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter Get the Newsletter!
- Froedtert & MCW Ranks Among Top 10 US Academic Medical Centers
- Corporate Chair Massage Program - It's Essential!
- Halloween Safety Tips
- Dr. Kiran K. Turaga named Sharon K. Wadina Endowed Professor in Sarcoma Research
- Milwaukee Backgammon Club: October schedule
- Happy 10th Anniversary Hart Park Square!
- MCW announces Critical Care Pediatric Nurse Practitioner Fellowship Program
- MCW’s Advancing a Healthier Wisconsin Endowment awards $250,000 to assess health impact of Eau Claire community planning
- Seniors can learn tips for downsizing in free presentation Oct. 6
- MCW awarded $2.7 million grant to advance the understanding and measurement of outcomes in children with chronic disease