NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
41°
H 41° L 30°
Clear | 5MPH

New Approaches in Treating Complicated Childhood Polycystic Kidney Disease

April 28, 2013

A collaborative team of physician-scientists at the Medical College of Wisconsin (MCW) and Children’s Hospital of Wisconsin Research Institute has developed a new evidence-based, clinical algorithm to help physicians treat complex patients with autosomal recessive polycystic kidney disease (ARPKD).

Their invited manuscript, written by Grzegorz Telega, MD, associate professor of pediatrics (gastroenterology and hepatology) at MCW and program director of hepatology at Children’s Hospital of Wisconsin; David Cronin, II, MD, PhD, professor of surgery and member of the new Transplantation Institute; and Ellis D. Avner, MD professor of pediatrics (nephrology) and physiology at MCW, and director of the Multidisciplinary Childhood PKD Program (MCPP) at Children’s Hospital of Wisconsin Research Institute, appears in the April 17 edition of Pediatric Transplantation http://onlinelibrary.wiley.com/doi/10.1111/petr.12076/full.

ARPKD is a rare genetic disorder that causes progressive disease of the kidneys and liver. Of the patients with ARPKD who survive the first year of life, more than 85 percent will reach their tenth birthday. However, despite dramatic improvements in overall survival and quality of life, nearly 50 percent of those survivors develop end stage kidney disease during that time.

Based on a comprehensive analysis of published medical literature, unique insights generated from the MCPP (established in 2005 and the only such program in the U.S.) and more than 50 years of clinical experience by the authors in treating complex problems in ARPKD patients, an algorithm was developed to guide patient therapy. Of particular note, the authors recommend an innovative approach for a subgroup of ARPKD patients with severe kidney and liver disease: simultaneous kidney and liver transplantation.

“We believe combined liver-kidney transplantation can potentially decrease overall mortality and morbidity in carefully selected ARPKD patients with end stage renal disease and clinically significant congenital hepatic fibrosis,” said Dr. Avner. “This is a particularly attractive option at our center, given the rapid growth of the joint solid organ transplantation program between Children’s Hospital of Wisconsin, Froedtert Hospital, the Medical College of Wisconsin, and the BloodCenter of Wisconsin, directed by Dr. Johnny Hong.”

The authors also emphasize that this therapy only be considered in major pediatric organ transplant centers with experienced pediatric transplant surgeons, subspecialty physicians and nurses, and complete pediatric ancillary services. The commentary also includes a “tree” to help guide clinicians making decisions about the appropriate course of treatment for complications of ARPKD.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Ask NOW: When will the lanes on Burleigh Street near Highway 45 be less confusing? 4/15

» In helping others, Bachman became 'Mr. Wauwatosa' 4/12

» City says goodbye to 'Mr. Wauwatosa' 4/9

» Three new Bartolotta restaurants announced for Mayfair Collection 4/8

» Vukmir releases records related to ALEC work 4/4

» Voters disagree with Citizens United ruling 4/2

» Brian Bawden elected to Wauwatosa School Board 4/1

» Jason Kofroth elected District 7 alderman 4/1

» Michael Walsh elected District 4 alderman 4/1

» Matt Stippich wins District 1 aldermanic seat 4/1

» Body found in Tosa identified as James Kieckbusch, 57 4/1

» Body found at border of Elm Grove and Wauwatosa Updated:  4/1

» Michael Lovell's move is a net gain for Milwaukee, business leaders say 3/26

» Wauwatosa police seek suspect in BMO Harris Bank robbery 3/14

» Firm in line for $7.2 million MMSD contract didn't show qualifications Updated:  3/11

» West advances with 75-4 win over James Madison 3/4

» Milwaukeeans share paczki on social media 3/4

» Whitefish Bay finds its tempo, downs Tosa East 2/28

» Messmer rallies to beat Tosa West 2/28

» East's Wheeler's free throws lead to upset of Shorewood 2/25

» Wauwatosa West 'We the People' team making another run in national competition 2/25

» Menomonee River Parkway segment closed to through traffic 2/24

» Salmon's 31 sparks Raiders past Spartans, 50-34 2/21

» Jury fails to reach verdict in firearm silencer case for gun collector 2/20

» Lawyer testifies why he bought silencer during reverse sting Updated:  2/20

View All Posts Got a tip? Welcome rss
Deal Watch - Milwaukee

Milwaukee's Best Discounts & Deals

Local Business Directory

CONNECT