Our privacy policy has changed. By using this site, you agree to the Privacy Policy and Terms of Use. Dismiss

New Approaches in Treating Complicated Childhood Polycystic Kidney Disease

April 28, 2013

A collaborative team of physician-scientists at the Medical College of Wisconsin (MCW) and Children’s Hospital of Wisconsin Research Institute has developed a new evidence-based, clinical algorithm to help physicians treat complex patients with autosomal recessive polycystic kidney disease (ARPKD).

Their invited manuscript, written by Grzegorz Telega, MD, associate professor of pediatrics (gastroenterology and hepatology) at MCW and program director of hepatology at Children’s Hospital of Wisconsin; David Cronin, II, MD, PhD, professor of surgery and member of the new Transplantation Institute; and Ellis D. Avner, MD professor of pediatrics (nephrology) and physiology at MCW, and director of the Multidisciplinary Childhood PKD Program (MCPP) at Children’s Hospital of Wisconsin Research Institute, appears in the April 17 edition of Pediatric Transplantation http://onlinelibrary.wiley.com/doi/10.1111/petr.12076/full.

ARPKD is a rare genetic disorder that causes progressive disease of the kidneys and liver. Of the patients with ARPKD who survive the first year of life, more than 85 percent will reach their tenth birthday. However, despite dramatic improvements in overall survival and quality of life, nearly 50 percent of those survivors develop end stage kidney disease during that time.

Based on a comprehensive analysis of published medical literature, unique insights generated from the MCPP (established in 2005 and the only such program in the U.S.) and more than 50 years of clinical experience by the authors in treating complex problems in ARPKD patients, an algorithm was developed to guide patient therapy. Of particular note, the authors recommend an innovative approach for a subgroup of ARPKD patients with severe kidney and liver disease: simultaneous kidney and liver transplantation.

“We believe combined liver-kidney transplantation can potentially decrease overall mortality and morbidity in carefully selected ARPKD patients with end stage renal disease and clinically significant congenital hepatic fibrosis,” said Dr. Avner. “This is a particularly attractive option at our center, given the rapid growth of the joint solid organ transplantation program between Children’s Hospital of Wisconsin, Froedtert Hospital, the Medical College of Wisconsin, and the BloodCenter of Wisconsin, directed by Dr. Johnny Hong.”

The authors also emphasize that this therapy only be considered in major pediatric organ transplant centers with experienced pediatric transplant surgeons, subspecialty physicians and nurses, and complete pediatric ancillary services. The commentary also includes a “tree” to help guide clinicians making decisions about the appropriate course of treatment for complications of ARPKD.

Community Watch

» Name revealed of new female giraffe at Milwaukee Co. Zoo 5/26

» Wauwatosa law enforcement honors fallen officers during national bike tour Updated:  5/26

» Tosa Top 5: Five things you need to know about in Wauwatosa this week 5/25

» Wauwatosa West boys finish fourth at Woodland Relays 5/25

» Wauwatosa West girls soccer team wins Woodland Conference championship 5/25

» Wauwatosa East soccer team splits two games, loses Lily Brock to injury 5/25

» Wauwatosa East girls finish seventh at GMC Outdoor Track and Field Meet 5/25

» Wauwatosa East boys fourth at GMC Outdoor Track and Field Meet 5/25

» State Street road work may be the biggest headache this year in Wauwatosa 5/25

» Wauwatosa Sports Notes: May 26, 2016 5/24

» Milwaukee County Chargers defeat Bulldogs in exhibition opener, 20-6 5/24

» Wauwatosa officer rescues seven ducklings trapped in storm sewer 5/24

» Initial Reaction: Talking with star Waukesha soccer players Dani Rhodes, Emily Cervantes Updated:  5/24

» Wauwatosa Police Report: May 15 - 21 5/24

» Wauwatosa West girls track team runs away with Woodland Outdoor title 5/24

» Video: Reporter takes us along the 2016 Run Tosa Run 5/23

» Tosa Top 5: Five things you need to know about in Wauwatosa this week 5/20

» Suspects charged in string of armed robberies through Wauwatosa, Milwaukee Updated:  5/19

» New Mayfair GM announces plans for a Z Gallerie furniture store Updated:  5/18

» Wauwatosa East baseball team will rely on defense, depth in 2016 5/18

» Wauwatosa East softball teams beats West Allis Central in twinbill 5/18

» Campus News: May 19 5/18

» Sports Shorts: May 19, 2016 5/18

» Wauwatosa East girls soccer team crushes West Allis Central, 11-0 5/18

» Wauwatosa West girls soccer team seeks Woodland title 5/18

View All Posts Got a tip? Welcome rss

Best Summer Ever

 

We've made it easy for you to get out and go this summer. From hitting the trails for a bike ride or walk, to where to find beer gardens in the area, to the best places to swim in Waukesha County to the best summer drinks and summer reads, check out our 2016 summer guide.

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where our Wauwatosa reporter explores the closed down and closed off parts of Wauwatosa.

Advertisement

CONNECT