Medical College of Wisconsin researcher to investigate enzymes involved in fatty acid oxidation

April 24, 2013

The Medical College of Wisconsin received a four-year, $1.5 million award from the National Institute of General Medical Sciences, National Institutes of Health to study the structure and function of enzymes involved in fatty acid oxidation.

Jung-Ja P. Kim, PhD, professor of biochemistry, is the principal investigator for the grant.

All cells in the human body require energy to maintain their structural integrity and to perform their vital functions. The major portion of this energy comes from the metabolism of fatty acids in heart, liver, and muscle cells. A failure or imbalance of this process causes fatty acid oxidation disorders, which occur in two to three out of every thousand births in the United States, and lead to conditions including sudden infant death syndrome, cardiomyopathy, and skeletal myopathy.

Little is known about the assembly of key enzymes involved in the reactions that govern this process. Dr. Kim’s lab will use X-ray crystallography to reveal the structures of a number of enzymes crucial to the fatty acid oxidation process. This understanding will help researchers determine how the enzymes function and interact with one another to facilitate the production of energy.

The insights gained from this project will advance our knowledge about fatty acid oxidation, and may help scientists find new targets for potential therapies to treat specific metabolic disorders.

Community Watch

» Wauwatosa's 22nd Secret Garden Tour scheduled for July 9 04:14 PM

» Wauwatosa Village businesses remain upbeat amid ongoing reconstruction Updated:  12:50 PM

» Initial Reaction Podcast: A look ahead to US Open 2017, look back at Champions Tour event in Madison Updated:  6/29

» Seventh-inning rally sparks Wauwatosa East over West, 5-4 6/29

» Tosa police investigating armed robbery at North Shore Bank Wednesday 6/29

» Wauwatosa East baseball team stays hot 6/29

» Wauwatosa East's Bueckers nabs all-state honors for girls soccer 6/29

» Wauwatosa West baseball snaps skid with wins over Eisenhower 6/29

» Irish Fest gears up for week of classes at Tosa's CelticMKE Center 6/28

» Tosa Skateboarders United hosts first event since opening of new park 6/28

» Friends of Center Street Park will launch new barbecue event July 3 6/28

» Long-tenured sports writer Sky Skibosh heads into retirement, sort of 6/26

» Family, friends of man killed by Wauwatosa officer want answers 6/25

» Tosa man with gun trove to plead guilty of illegal dealing 6/24

» Wauwatosa endorses bus rapid transit route, more approvals needed Updated:  6/23

» Video: Tosa Top 5: Five things you need to know about in Wauwatosa this week 6/23

» Wauwatosa officer fatally shoots man at Madison Park 6/23

» Wauwatosa Public Library announces list of summer events 6/22

» Blood drives scheduled for Milwaukee County during month of July 6/22

» Two lanes on Wauwatosa's Harmonee Bridge to close Thursday 6/22

» Milwaukee Co. Zoo welcomes baby harbor seal, bonobo 6/22

» Teens accused of trying to rob Tosa resident with BB gun Updated:  6/22

» Hidden Tosa: Inside the Wauwatosa Police Department 6/22

» Offense holding back Wauwatosa West baseball team 6/21

» Wauwatosa East baseball wins four conference games 6/21

View All Posts Got a tip? Welcome rss

Best Summer Ever

 

We've made it easy for you to get out and go this summer. From hitting the trails for a bike ride or walk, to where to find beer gardens in the area, to the best places to swim in Waukesha County to the best summer drinks and summer reads, check out our 2016 summer guide.

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where our Wauwatosa reporter explores the closed down and closed off parts of Wauwatosa.

Advertisement

CONNECT