MCW Researcher to Study Evasive Immune Strategies of Herpesviruses

March 20, 2013

The Medical College of Wisconsin has received a two-year, $476,000 grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to study immune response to certain herpesviruses.

Amy W. Hudson, PhD, associate professor of microbiology and molecular genetics, is the primary investigator of the grant.

Human herpesviruses -6 and -7 infect essentially the world’s entire population before the age of five. Like all herpesviruses, these viruses remain latent or persistent throughout life. HHV-6 and -7 (Roseoloviruses) are common childhood illnesses. In most children, infection with HHV -6 or -7 causes a fever, which can be quite high; in some cases, these high fevers cause seizures. Recent studies suggest that these febrile seizures are associated with increased risk of developing epilepsy later in life.

Since herpesviruses remain latent or persistent within us throughout life, they must necessarily excel at escaping immune detection throughout the life of the host. Because HHV-6 and -7 infect only humans, an animal model in which to study how these viruses interact with and thwart immune detection does not exist.

In this project, Dr. Hudson will develop a mouse model with a “humanized” immune system to study the mechanisms by which these viruses evade detection by the immune system. This will lead to a better understanding of acute and latent infection, and may have future clinical application in the treatment of epilepsy and autoimmune disorders.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» What residents in Southeast Wisconsin need to know to prevent the spread of Zika virus 2/10

» For Wauwatosa Hurricanes' Danny Larson, it's all about the team 2/10

» Wauwatosa West boys basketball team bounces back to beat New Berlin West 2/10

» Wauwatosa West girls basketball team drops five in a row 2/10

» Wauwatosa East girls basketball team defeats Menomonee Falls to snap 3-game losing streak 2/10

» Big Cheese Classic National Wheelchair Basketball tourney set for Feb. 20-21 2/10

» Wauwatosa's Larson wins two swimming championship 2/10

» Wauwatosa East boys basketball team drops third straight game 2/10

» Five Wauwatosa East student-athletes to play at collegiate level 2/10

» Wauwatosa's Beekman to play football at Southern A&M 2/10

» Tosa officers return to work following police-involved shooting 2/9

» Fat Tuesday: How Wauwatosa celebrated 2/9

» As trial begins, man pleads guilty to shooting Wauwatosa police officer Updated:  2/8

» Tosa's All-City Read well underway, more events to come 2/8

» Wauwatosa Revolving Loan Fund celebrates 25 years 2/8

» Milwaukee Co. Zoo welcomes two new lionesses 2/8

» Updated rankings of area prep boys and girls basketball teams and players 2/8

» Wauwatosa West boys basketball team defeats Shorewood, South Milwaukee 2/3

» Marquette gets revenge with 75-55 victory over Wauwatosa East boys 2/3

» Wauwatosa East's Stewart, Green combine for 49 points in win over Brookfield Central 2/3

» Wauwatosa West girls basketball team loses road games to Shorewood, South Milwaukee 2/3

» Wauwatosa Hurricanes finish second at Bob White Swimming Invitational 2/3

» Wauwatosa Tosa girls basketball team drops tough decisions to Lancers, Chargers 2/3

» Pewaukee whips Wauwatosa wrestlers to take first in conference 2/3

» Positive and uplifting stories in suburban Milwaukee and Lake Country in January 2/1

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporters Rory Linnane or Rachel Minske explore the closed down and closed off parts of Wauwatosa.

Advertisement

Election center 2016

Election overage from from the MyCommunityNow coverage area covering suburban Milwaukee County and the eastern half of Waukesha County.

Suburban Milwaukee election center 2016

Local Business Directory

CONNECT