H 64° L 52°
Clear | 5MPH

Medical College of Wisconsin Researcher to Study Dystrophic Cardiomyopathy

Nov. 27, 2012

The Medical College of Wisconsin (MCW) received a five-year, $650,000 award from the National Institutes of Health’s National Heart, Lung and Blood Institute to investigate how muscular dystrophy causes cardiac muscle to deteriorate, a condition known as dystrophic cardiomyopathy.

Jennifer L. Strande, M.D., Ph.D., assistant professor of medicine – cardiovascular and a cardiologist at Froedtert & The Medical College, is the principal investigator for the grant. This grant supports a five-year career development plan. Dr. Strande’s mentor for the project is Zeljko Bosnjak, Ph.D., professor and vice chairman for research in anesthesiology at the Medical College.

Muscular dystrophy is a genetic disease in which patients suffer a progressive loss of muscle strength and function. The most common forms, Duchenne and Becker muscular dystrophy, are found in 400 to 600 newborn boys in the United States each year, according to the Centers for Disease Control and Prevention. In addition to affecting the skeletal muscles that operate voluntary movement, muscular dystrophy can also weaken heart function and threaten the patient’s cardiovascular health. Duchenne muscular dystrophy is the most common fatal genetic disease and heart failure is an emerging threat to these patients.

In this project, Dr. Strande will study the first human model of dystrophic cardiomyopathy by using heart cells derived from induced pluripotent stem cells, which are skin cells taken from patients and reprogrammed to function like stem cells. Her lab will run tests to determine how the various muscular dystrophy mutations affect heart cells. The team will also assess a possible treatment option that may help protect the heart from stress and damage in cases of muscular dystrophy.

The results of this investigation may generate new understanding about how the genetic mutations in muscular dystrophy affect muscle in the heart. Dr. Strande’s efforts may also lead to new ideas for improving the treatment of muscular dystrophy patients with cardiovascular concerns.



This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.

Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Nordstrom Mayfair announces gala, late-night party fundraising events 09:03 AM

» Aurora plans $35 million upgrade to psychiatric hospital in Tosa Updated:  10/2

» Updated week seven rankings of area prep football teams and players Updated:  10/2

» Mayfair mall, Susan G. Komen host series of breast cancer events 10/2

» Wauwatosa schools celebrate Walk to School Day on Oct. 7 10/2

» Initial Reaction Podcast: Is Aaron Rodgers really the best QB in football? 10/1

» Wauwatosa West football whips Pius XI in wild scoring affair 9/29

» Tosa West boys split two matches 9/29

» East kickers tie, lose, win during busy week 9/29

» Tosa East girls take third at Bay Invitational 9/29

» East's Potter finishes second at Nikolai Invite 9/29

» Wauwatosa Sports Shorts Oct. 1 9/29

» Tosa fourth in GMC golf standings 9/29

» 3 things you can do to protect your family, pets from coyote attacks Updated:  9/29

» City of Wauwatosa discussing 2016 executive budget 9/28

» Tosa fire dept. offers CPR class Oct. 17 9/28

» Wauwatosa public invited to chat with education author 9/28

» Nine local office positions in Tosa will be on spring election ballot 9/25

» Comiskey's hat trick leads Bay soccer team past Tosa East, 5-1 9/24

» Public meeting to discuss Wauwatosa coyote problem scheduled Oct. 6 Updated:  9/24

» Tosa Farmers Market to host biking event Sept. 26 9/23

» Echelon Apartments ready to open at Innovation Campus in Wauwatosa 9/23

» Bucks set Fanfest for Oct. 3 9/23

» Wauwatosa East Sports Shorts: Sept. 24, 2015 9/23

» Trojans win Wisconsin Rapids Invite 9/23

View All Posts Got a tip? Welcome rss



Hidden Tosa


"Hidden Tosa" is a semi-regular feature where reporters Rory Linnane or Rachel Minske explore the closed down and closed off parts of Wauwatosa.


Local Business Directory