Medical College of Wisconsin Researcher to Study Dystrophic Cardiomyopathy

Nov. 27, 2012

The Medical College of Wisconsin (MCW) received a five-year, $650,000 award from the National Institutes of Health’s National Heart, Lung and Blood Institute to investigate how muscular dystrophy causes cardiac muscle to deteriorate, a condition known as dystrophic cardiomyopathy.

Jennifer L. Strande, M.D., Ph.D., assistant professor of medicine – cardiovascular and a cardiologist at Froedtert & The Medical College, is the principal investigator for the grant. This grant supports a five-year career development plan. Dr. Strande’s mentor for the project is Zeljko Bosnjak, Ph.D., professor and vice chairman for research in anesthesiology at the Medical College.

Muscular dystrophy is a genetic disease in which patients suffer a progressive loss of muscle strength and function. The most common forms, Duchenne and Becker muscular dystrophy, are found in 400 to 600 newborn boys in the United States each year, according to the Centers for Disease Control and Prevention. In addition to affecting the skeletal muscles that operate voluntary movement, muscular dystrophy can also weaken heart function and threaten the patient’s cardiovascular health. Duchenne muscular dystrophy is the most common fatal genetic disease and heart failure is an emerging threat to these patients.

In this project, Dr. Strande will study the first human model of dystrophic cardiomyopathy by using heart cells derived from induced pluripotent stem cells, which are skin cells taken from patients and reprogrammed to function like stem cells. Her lab will run tests to determine how the various muscular dystrophy mutations affect heart cells. The team will also assess a possible treatment option that may help protect the heart from stress and damage in cases of muscular dystrophy.

The results of this investigation may generate new understanding about how the genetic mutations in muscular dystrophy affect muscle in the heart. Dr. Strande’s efforts may also lead to new ideas for improving the treatment of muscular dystrophy patients with cardiovascular concerns.



This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.

Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» 10-year-old girl dies after freeway crash in Dane County 11/25

» Wauwatosa unveils convenient, affordable water online water bill payment options 11/25

» Wauwatosa East girls basketball team uses big second half to beat Wisconsin Lutheran 11/25

» Plenty of positives in Wauwatosa West girls' basketball loss to Kettle Moraine 11/25

» Wauwatosa East boys basketball team could battle for GMC title 11/25

» Wauwatosa West swimming team has bright future with talented underclassmen on the rise 11/25

» MacGillis, Barkow share Wauwatosa West boys volleyball MVP honors 11/25

» Wauwatosa West boys basketball team looks for improvement 11/25

» Sports Notes: Nov. 26, 2015 11/25

» Wauwatosa East volleyball season has solid season despite just missing another trip to state 11/25

» Wauwatosa Hurricanes return three state qualifiers — Danny Larson, Cal Hartt, Avery Weishoff 11/25

» Milwaukee County Zoo celebrates first birthday of young gorilla 11/24

» Wauwatosa stores set Thanksgiving, Black Friday hours 11/23

» Tosa's city health department earns national accreditation 11/23

» Free screening of 'Most Likely to Succeed' held Dec. 1 11/23

» Wauwatosa stores launch Small Business Saturday event 11/20

» Updated state championship game rankings of area prep football teams and players 11/19

» Wauwatosa dealership taking 'extra precautions' after four vehicles were stolen Updated:  11/19

» Wauwatosa East girls basketball team has plenty of experience returning 11/18

» Wauwatosa East's Potter earns two team cross-country awards 11/18

» Wauwatosa West girls to field experienced basketball team 11/18

» Wauwatosa East's Ripple ends career with impressive showing at state swimming meet 11/18

» Wauwatosa West freshman Julia Larson does well at state swimming championships 11/17

» Wauwatosa West's Alicia Picard, Alyssa Piek, Nicole Mystrow earn top tennis honors 11/17

» Christian Laettner hoops camps at Wauwatosa East successful 11/17

View All Posts Got a tip? Welcome rss



Hidden Tosa


"Hidden Tosa" is a semi-regular feature where reporters Rory Linnane or Rachel Minske explore the closed down and closed off parts of Wauwatosa.


Local Business Directory