H 70° L 52°
Cloudy | 7MPH

Using “Killer Cells” to Treat High-Risk Pediatric Tumors

Nov. 15, 2012

Scientists from the Medical College of Wisconsin (MCW), Children’s Hospital of Wisconsin and the BloodCenter of Wisconsin received a one-year, $50,000 grant from the Clinical and Translational Science Institute of Southeast Wisconsin (CTSI) to study new methods to treat solid tumors in pediatric patients.

The primary investigator on the study is Monica Thakar, M.D., assistant professor of pediatrics - hematology and oncology and bone marrow transplant at MCW and investigator at Children’s Research Institute. Co-primary investigators are Subramaniam Malarkannan, Ph.D., associate professor of medicine - hematology and oncology at the Medical College and investigator at the Blood Research Institute; Meghen Browning, M.D., assistant professor of pediatrics - hematology and oncology at MCW and pediatric oncologist at Children’s Hospital; and Kristina Schuldt, B.S., research assistant at the Blood Research Institute.

This Phase I/II study uses a dual immunotherapy approach to treat patients with high-risk malignant solid tumors. In the clinical trial, researchers will use natural killer (NK) cells and allogeneic hematopoietic stem cells to treat high-risk refractory patients with solid tumors. The study also seeks to evaluate the relationship between different NK cell phenotypes and the cytokines and chemokines that emerge from this approach.

This is one of 19 pilot projects being funded in 2012 through CTSI. The goal is to create synergy through collaboration, and studies are specifically designed to lead to major future research support. The projects explore findings that have the potential to be translated into clinical practice and community health, and are led by investigators at the CTSI’s eight partnering institutions: the Medical College of Wisconsin, Marquette University, Milwaukee School of Engineering, UW-Milwaukee, Froedtert Hospital, Children’s Hospital of Wisconsin, the VA Medical Center, and the BloodCenter of Wisconsin.

CTSI is part of a national consortium of top medical research institutions. Working together, the CTSI institutions are committed to improve human health by streamlining science, transforming training environments and improving the conduct, quality and dissemination of clinical and translational research. The CTSI program is led by the National Center for Advancing Translational Sciences, part of the National Institutes of Health.

Support for the Pilot Award Program comes from the National Institutes of Health, the John and Jeanne Byrnes CTSI Award, and both MCW’s Advancing a Healthier Wisconsin program, and MCW’s Biotechnology and Bioengineering Center.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.

Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Bedbugs found in Wauwatosa juvenile court center Updated:  05:35 PM

» Nordstrom Mayfair announces gala, late-night party fundraising events 09:03 AM

» Aurora plans $35 million upgrade to psychiatric hospital in Tosa Updated:  10/2

» Updated week seven rankings of area prep football teams and players Updated:  10/2

» Mayfair mall, Susan G. Komen host series of breast cancer events 10/2

» Wauwatosa schools celebrate Walk to School Day on Oct. 7 10/2

» Initial Reaction Podcast: Is Aaron Rodgers really the best QB in football? 10/1

» Wauwatosa West football whips Pius XI in wild scoring affair 9/29

» Tosa West boys split two matches 9/29

» East kickers tie, lose, win during busy week 9/29

» Tosa East girls take third at Bay Invitational 9/29

» East's Potter finishes second at Nikolai Invite 9/29

» Wauwatosa Sports Shorts Oct. 1 9/29

» Tosa fourth in GMC golf standings 9/29

» 3 things you can do to protect your family, pets from coyote attacks Updated:  9/29

» City of Wauwatosa discussing 2016 executive budget 9/28

» Tosa fire dept. offers CPR class Oct. 17 9/28

» Wauwatosa public invited to chat with education author 9/28

» Nine local office positions in Tosa will be on spring election ballot 9/25

» Comiskey's hat trick leads Bay soccer team past Tosa East, 5-1 9/24

» Public meeting to discuss Wauwatosa coyote problem scheduled Oct. 6 Updated:  9/24

» Tosa Farmers Market to host biking event Sept. 26 9/23

» Echelon Apartments ready to open at Innovation Campus in Wauwatosa 9/23

» Bucks set Fanfest for Oct. 3 9/23

» Wauwatosa East Sports Shorts: Sept. 24, 2015 9/23

View All Posts Got a tip? Welcome rss



Hidden Tosa


"Hidden Tosa" is a semi-regular feature where reporters Rory Linnane or Rachel Minske explore the closed down and closed off parts of Wauwatosa.


Local Business Directory