Medical College of Wisconsin and Children’s Hospital of Wisconsin to investigate autoantibody production in autoimmune disorders

Oct. 8, 2012

The Medical College of Wisconsin and Children’s Hospital of Wisconsin Research Institute received a one-year award for more than $375,000 from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases. The award will fund an investigation of the factors involved in regulating the production of autoantibodies, which are antibodies that target an individual’s own tissues. These autoantibodies are linked to autoimmune disorders like lupus and rheumatoid arthritis.

Stephen Gauld, Ph.D., assistant professor of pediatrics in allergy and immunology, and microbiology and molecular genetics, and a researcher at the Research Institute, is the principal investigator for the grant.

The National Institutes of Health estimated in 2005 that between 15 and 24 million Americans suffer from one of the more than 80 diseases in the autoimmune disorder family. Many of these chronic diseases have no cure and disproportionally impact women. Patients are often debilitated by their symptoms and the high costs of a lifetime of treatment.

This project seeks to understand the factors that influence the production of autoantibodies that attack a patient’s own tissues in cases of autoimmune disease. Prior research in Dr. Gauld’s lab has shown that a cell in the immune system, the regulatory T cell, suppresses the production of autoantibodies by other immune cells called B cells. Dr. Gauld will study this reaction to understand how it works and how it can be manipulated to reduce tissue damage and promote patient health.

The results of this study will advance understanding of autoantibody production and help researchers discover novel treatments to slow down or prevent the generation of antibodies that attack the body’s tissues.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.

Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Wauwatosa firefighters captured on video battling car flames 04:02 PM

» German retailer VOM FASS opens at Mayfair Mall 03:00 PM

» Updated rankings of area prep boys and girls basketball teams and players 12:10 PM

» Wauwatosa man involved in fatal Dane County crash 10:29 AM

» Stone Creek Coffee looks to open Harwood Avenue location in Tosa 09:47 AM

» 10-year-old girl dies after freeway crash in Dane County 11/25

» Wauwatosa unveils convenient, affordable water online water bill payment options 11/25

» Wauwatosa East girls basketball team uses big second half to beat Wisconsin Lutheran 11/25

» Plenty of positives in Wauwatosa West girls' basketball loss to Kettle Moraine 11/25

» Wauwatosa East boys basketball team could battle for GMC title 11/25

» Wauwatosa West swimming team has bright future with talented underclassmen on the rise 11/25

» MacGillis, Barkow share Wauwatosa West boys volleyball MVP honors 11/25

» Wauwatosa West boys basketball team looks for improvement 11/25

» Sports Notes: Nov. 26, 2015 11/25

» Wauwatosa East volleyball season has solid season despite just missing another trip to state 11/25

» Wauwatosa Hurricanes return three state qualifiers — Danny Larson, Cal Hartt, Avery Weishoff 11/25

» Milwaukee County Zoo celebrates first birthday of young gorilla 11/24

» Wauwatosa stores set Thanksgiving, Black Friday hours 11/23

» Tosa's city health department earns national accreditation 11/23

» Free screening of 'Most Likely to Succeed' held Dec. 1 11/23

» Wauwatosa stores launch Small Business Saturday event 11/20

» Updated state championship game rankings of area prep football teams and players 11/19

» Wauwatosa dealership taking 'extra precautions' after four vehicles were stolen Updated:  11/19

» Wauwatosa East girls basketball team has plenty of experience returning 11/18

» Wauwatosa East's Potter earns two team cross-country awards 11/18

View All Posts Got a tip? Welcome rss



Hidden Tosa


"Hidden Tosa" is a semi-regular feature where reporters Rory Linnane or Rachel Minske explore the closed down and closed off parts of Wauwatosa.


Local Business Directory