Medical College of Wisconsin Receives Grant from the St. Baldricks Foundation for Cancer Research
The Medical College of Wisconsin (MCW) received a one year, $50,275 supportive care research grant from the St. Baldrick’s Foundation to study new therapies for hearing loss in pediatric cancer patients.
Fritz Sieber, Ph.D., professor of pediatrics and medicine at MCW with joint appointments in the Department of Cell Biology, Neurobiology & Anatomy and the Department of Microbiology and Molecular Genetics, and a researcher at Children’s Hospital of Wisconsin Research Institute, is the primary investigator of the grant. Co-investigators are Christina Runge, Ph.D., associate professor of otolaryngology and communication sciences at MCW; and David Friedland, M.D., Ph.D., professor and vice chair of otolaryngology and communication sciences at MCW.
About half of children and adolescents who become long-term cancer survivors develop therapy-induced hearing loss that is cumulative and irreversible. The patients most at risk are those with brain tumors and other cancers that require treatment with drugs called “platins,” combined with radiation to the head and neck.
This hearing loss adversely affects speech, reading ability, communication, academic performance and overall psychosocial development, which sometimes leads to low self-esteem and social isolation.
In this research project, Dr. Sieber and his team will investigate the use of high doses of dietary selenium to prevent cisplatin-induced hearing loss. The researchers will use a rat model to activate pathways to prevent hearing loss more effectively than conventional antioxidants.
“Selenium has been shown to be effective in mitigating other forms of radiation injury to normal tissue,” said Dr. Sieber. “We are hopeful that selenium will be shown to reduce this devastating side effect of cancer treatments, and we are grateful for the St. Baldrick’s Foundation for their support of this project.”
Dan Devine, the mayor of West Allis, Wis., which held its third St. Baldrick’s event this summer, said, “These events always bring the community together, are lots of fun and raise money for an incredibly valuable cause. Learning that the money raised by the St. Baldrick’s Foundation will go directly to the Medical College of Wisconsin, it makes it even more special.”
Your link to the biggest stories in the suburbs delivered Thursday mornings.
Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter Get the Newsletter!
- Seeking Adult Day Services Program Volunteers at Lutheran Home
- Car Seat and Booster Safety Check
- Greater Brookfield Chamber of Commerce continues sponsorship of “Social Media Tools for Business” workshop for regional businesses
- LearningRx Hosts May 30 Open House
- Greater Brookfield Chamber of Commerce continues to add new members
- Daylily Society of SE WI/daylily sale
- Wisconsin Kitchen Mart Takes the Mystery Out of Remodeling
- Tosa West Orchestra Students Honored
- MCW researcher to study gene therapies for hemophilia
- Individuals Encouraged to Join Playworks Wisconsin 4th Annual Corporate Kickball Tournament