Medical College researcher to study protein linked to diabetes and liver disease

July 13, 2012

The Medical College of Wisconsin received a four-year, $1.3 million grant from the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases. The award will fund an investigation of a key regulatory protein linked to diabetes and liver disease.

Lisa Ann Cirillo, Ph.D., associate professor of cell biology, neurobiology and anatomy, is the principal investigator for the grant.

Mutations in the regulatory protein, FoxO1, have been linked to the development of diabetes and liver disease. Diabetes affects 25.8 million children and adults in the United States. Complications of the disease include heart disease, stroke, blindness, kidney disease and neurological disease. The cost of diabetes annually is estimated at $174 billion in the United States alone.

Liver diseases linked to the FoxO1 protein include hepatic steatosis, or fatty liver, which can be a serious disease in pregnant women. FoxO1 is also linked to hepatic fibrosis, an abnormal protein build-up that can damage the liver and lead to cirrhosis and liver failure.

Investigators on Dr. Cirillo’s research team will use human induced pluripotent stem cells (hiPS), adult cells transformed into stem cells for the purposes of research, to explore how the FoxO1 protein regulates the development and function of liver cells. The researchers will also utilize innovative methods to analyze the structure of proteins involved in the expression of FoxO1.

This project will lead to improved understanding of the regulation of this protein related to metabolism and liver function, which will contribute to the development of new therapies for patients with diabetes and liver disease.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.

Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» 10-year-old girl dies after freeway crash in Dane County 11/25

» Wauwatosa unveils convenient, affordable water online water bill payment options 11/25

» Wauwatosa East girls basketball team uses big second half to beat Wisconsin Lutheran 11/25

» Plenty of positives in Wauwatosa West girls' basketball loss to Kettle Moraine 11/25

» Wauwatosa East boys basketball team could battle for GMC title 11/25

» Wauwatosa West swimming team has bright future with talented underclassmen on the rise 11/25

» MacGillis, Barkow share Wauwatosa West boys volleyball MVP honors 11/25

» Wauwatosa West boys basketball team looks for improvement 11/25

» Sports Notes: Nov. 26, 2015 11/25

» Wauwatosa East volleyball season has solid season despite just missing another trip to state 11/25

» Wauwatosa Hurricanes return three state qualifiers — Danny Larson, Cal Hartt, Avery Weishoff 11/25

» Milwaukee County Zoo celebrates first birthday of young gorilla 11/24

» Wauwatosa stores set Thanksgiving, Black Friday hours 11/23

» Tosa's city health department earns national accreditation 11/23

» Free screening of 'Most Likely to Succeed' held Dec. 1 11/23

» Wauwatosa stores launch Small Business Saturday event 11/20

» Updated state championship game rankings of area prep football teams and players 11/19

» Wauwatosa dealership taking 'extra precautions' after four vehicles were stolen Updated:  11/19

» Wauwatosa East girls basketball team has plenty of experience returning 11/18

» Wauwatosa East's Potter earns two team cross-country awards 11/18

» Wauwatosa West girls to field experienced basketball team 11/18

» Wauwatosa East's Ripple ends career with impressive showing at state swimming meet 11/18

» Wauwatosa West freshman Julia Larson does well at state swimming championships 11/17

» Wauwatosa West's Alicia Picard, Alyssa Piek, Nicole Mystrow earn top tennis honors 11/17

» Christian Laettner hoops camps at Wauwatosa East successful 11/17

View All Posts Got a tip? Welcome rss



Hidden Tosa


"Hidden Tosa" is a semi-regular feature where reporters Rory Linnane or Rachel Minske explore the closed down and closed off parts of Wauwatosa.


Local Business Directory