NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
48°
H 54° L 30°
Clear | 6MPH

Medical College researcher to study gene transcription

July 11, 2012

The Medical College of Wisconsin received a four-year, $1.2 million grant from the National Institutes of Health’s National Institute of General Medical Sciences. The grant will fund an investigation of the three-dimensional structure of the protein assembly that forms around RNA polymerase II (Pol II), the crucial enzyme that reads the genetic information stored on chromosomes and puts it into a form of biopolymer—RNA—that can then be used for protein synthesis.

Jianhua Fu, Ph.D., associate professor of biochemistry, is the principal investigator for the grant.

Pol II is responsible for “gene transcription,” which is the rewriting of the genetic code from DNA into RNA. RNA is responsible for providing the genetic information, or templates, used to make proteins. Those proteins carry out a vast array of biological tasks in the human body, such as the differentiation of stem cells into tissue during human development. Improper transcription is a common problem found in cancer cells that multiply excessively and become tumors.

Dr. Fu’s lab is interested in the 3-D structure of the Pol II machinery, which is the complex organized from several dozens of component proteins, because of its essential role in gene transcription. This investigation will use biochemical and molecular cloning techniques to generate samples for the study. The researchers will then utilize x-ray diffraction and computational methods to determine and verify structures of the protein complexes containing Pol II and regulatory proteins involved in transcription.

This research will improve our understanding of how gene transcription is regulated at a fundamental level. This work is an essential part of the world-wide research efforts to understand genetic regulation and its links to many forms of pathogenesis, particular diseases such as cancer that are resilient and resistant to current treatments.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Poll: Which area team will win a state football title? 09:00 AM

» Wauwatosa negotiating financial aid for Underwood apartments 10/22

» T.J. Maxx opening Oct. 30 in Wauwatosa 10/20

» Across Wisconsin, uneven property assessments fly in the face of fairness Updated:  10/19

» Preps football photos of the week: Week 9 10/17

» 500 free winter emergency kits given away at Mayfair tomorrow 10/17

» Camp Bar Tosa opens Saturday 10/17

» The Malt Shoppe grand opening party is Oct. 24-26 10/15

» JCPenney Furniture Outlet receives bomb threat 10/15

» Former Maharaja partner plans Indian restaurant for Wauwatosa 10/13

» New antique shop could replace Twirly Birds in Wauwatosa Village 10/13

» Preps football photos of the week: Week 8 10/10

» ID not required for voting 10/10

» Corner Bakery announces Oct. 20 opening 10/9

» Pizza Man to open second location at The Mayfair Collection 10/9

» Submit election letters now: deadline is Oct. 20 10/9

» No injuries in Wauwatosa house fire Sunday night 10/6

» Preps football photos of the week: Week 7 10/3

» Motorcyclist killed in East Tosa crash identified 10/3

» Police respond to two bomb threats at Kmart in Wauwatosa 10/3

» Man killed in Hwy. 45 crash identified, other driver arrested 10/1

» 'Rollover ejection crash' kills one, closes Hwy. 45 lanes for 5 hours Updated:  9/30

» East Tosa BID plan rejected 9/30

» Bankruptcy judge approves sale of YMCA properties 9/30

» Man killed in rollover crash on Highway 45 in Wauwatosa 9/30

View All Posts Got a tip? Welcome rss
Deal Watch - Milwaukee

Milwaukee's Best Discounts & Deals

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

Local Business Directory

CONNECT