NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
63°
H ° L °
Cloudy | 3MPH

Medical College researcher to study gene transcription

July 11, 2012

The Medical College of Wisconsin received a four-year, $1.2 million grant from the National Institutes of Health’s National Institute of General Medical Sciences. The grant will fund an investigation of the three-dimensional structure of the protein assembly that forms around RNA polymerase II (Pol II), the crucial enzyme that reads the genetic information stored on chromosomes and puts it into a form of biopolymer—RNA—that can then be used for protein synthesis.

Jianhua Fu, Ph.D., associate professor of biochemistry, is the principal investigator for the grant.

Pol II is responsible for “gene transcription,” which is the rewriting of the genetic code from DNA into RNA. RNA is responsible for providing the genetic information, or templates, used to make proteins. Those proteins carry out a vast array of biological tasks in the human body, such as the differentiation of stem cells into tissue during human development. Improper transcription is a common problem found in cancer cells that multiply excessively and become tumors.

Dr. Fu’s lab is interested in the 3-D structure of the Pol II machinery, which is the complex organized from several dozens of component proteins, because of its essential role in gene transcription. This investigation will use biochemical and molecular cloning techniques to generate samples for the study. The researchers will then utilize x-ray diffraction and computational methods to determine and verify structures of the protein complexes containing Pol II and regulatory proteins involved in transcription.

This research will improve our understanding of how gene transcription is regulated at a fundamental level. This work is an essential part of the world-wide research efforts to understand genetic regulation and its links to many forms of pathogenesis, particular diseases such as cancer that are resilient and resistant to current treatments.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Man killed in Hwy. 45 crash identified, other driver arrested 10/1

» 'Rollover ejection crash' kills one, closes Hwy. 45 lanes for 5 hours Updated:  9/30

» East Tosa BID plan rejected 9/30

» Bankruptcy judge approves sale of YMCA properties 9/30

» Man killed in rollover crash on Highway 45 in Wauwatosa 9/30

» Enter Halloween contest to win tickets to Legends & Lore 9/30

» Motorcyclist dies after collision on North Avenue in East Tosa 9/29

» Two-vehicle crash in Wauwatosa kills motorcyclist 9/29

» Hue serving first dinner in Tosa tonight 9/29

» Preps football photos of the week: Sept. 26 9/26

» Ronald McDonald House expansion means there'll be room in the inn Updated:  9/23

» Pedestrian killed in crash at Bluemound and Mayfair roads 9/23

» Poll: Will Wauwatosa West or Greendale win in Week 6 matchup? 9/23

» Auction for YMCAs called off after no new bidders emerge 9/22

» Apartment project proposed for Wauwatosa Village 9/22

» Preps football photos of the week: Sept. 19 9/19

» Tosa West rushes to 31-10 win over Eisenhower 9/19

» Vape Haven rejected by Wauwatosa Common Council 9/17

» Consideration overdue: Thievery marring Little Free Libraries 9/16

» Thai-namite plans fall through in East Tosa 9/15

» Preps football photos of the week: Sept. 12 9/12

» Chili'n on the Ave. is Saturday 9/12

» DSW Designer Shoe Warehouse opens tomorrow at Mayfair Collection 9/9

» TosaFest fight had no arrests or reported injuries, police say 9/9

» E-Cigarette store Vape Haven rejected by Tosa Plan Commission 9/8

View All Posts Got a tip? Welcome rss
Deal Watch - Milwaukee

Milwaukee's Best Discounts & Deals

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

Local Business Directory

CONNECT