The Medical College of Wisconsin received a four-year, $1.2 million grant from the National Institutes of Health’s National Institute of General Medical Sciences. The grant will fund an investigation of the three-dimensional structure of the protein assembly that forms around RNA polymerase II (Pol II), the crucial enzyme that reads the genetic information stored on chromosomes and puts it into a form of biopolymer—RNA—that can then be used for protein synthesis.
Jianhua Fu, Ph.D., associate professor of biochemistry, is the principal investigator for the grant.
Pol II is responsible for “gene transcription,” which is the rewriting of the genetic code from DNA into RNA. RNA is responsible for providing the genetic information, or templates, used to make proteins. Those proteins carry out a vast array of biological tasks in the human body, such as the differentiation of stem cells into tissue during human development. Improper transcription is a common problem found in cancer cells that multiply excessively and become tumors.
Dr. Fu’s lab is interested in the 3-D structure of the Pol II machinery, which is the complex organized from several dozens of component proteins, because of its essential role in gene transcription. This investigation will use biochemical and molecular cloning techniques to generate samples for the study. The researchers will then utilize x-ray diffraction and computational methods to determine and verify structures of the protein complexes containing Pol II and regulatory proteins involved in transcription.
This research will improve our understanding of how gene transcription is regulated at a fundamental level. This work is an essential part of the world-wide research efforts to understand genetic regulation and its links to many forms of pathogenesis, particular diseases such as cancer that are resilient and resistant to current treatments.
Your link to the biggest stories in the suburbs delivered Thursday mornings.
Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter Get the Newsletter!
- Abby Thompson will appear in Milwaukee Rep Theater's production of A Christmas Carol
- St. Margaret Mary School to Donate 13,200 Pounds of Food
- Richard Kohlmann Named Beverage Manager at Western Racquet Club
- Area Students Perform in Miracle on 34th Street at Sunset Playhouse December 4th through December 31st
- Acclaimed actor Michael York to keynote amyloidosis event
- YOUNG WAUWATOSA RESIDENT APPEARS IN FIRST STAGE'S RUDOLPH THE RED-NOSED REINDEER
- Shop Small on Small Business Saturday
- Milwaukee/NARI Home Improvement Council Honors Barry Mandel With the “Building Milwaukee” Award
- Local Businesses Collect, Deliver More than 4,000 Pounds of Food to New Berlin Food Pantry
- TOP 10 THINGS YOU NEED TO KNOW WHEN BUYING A HOME