The Medical College of Wisconsin (MCW) received a two-year, $420,000 grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to investigate a promising biological avenue for treating nerves affected by botulism.
Joseph T. Barbieri, Ph.D., professor of microbiology and molecular genetics and director of the Medical Scientist Training Program at MCW, is the principal investigator for the grant who will collaborate with MCW colleagues Allison Ebert, Ph.D., assistant professor of cell biology, neurobiology and anatomy, and Jung-Ja Kim, Ph.D., professor of biochemistry, to conduct this research.
Clostridium botulinum bacteria produce a nerve toxin that can cause botulism, a rare paralytic disease that afflicts approximately 145 people each year in the United States. Botulinum toxin is the most toxic protein for humans and classified as a “Category A Select Agent.” There is a limited supply of the vaccine used to treat the illness and no other approved therapies exist.
Dr. Barbieri will study a method to deliver therapies to diseased nerves. The effectiveness of this method for treating specific nerves affected by the botulinum toxin will be tested in mouse models.
This is one of the first R21/R33 grants, a new funding mechanism at the NIH, awarded to MCW. A two-year R21 grant may be transitioned into a longer-term, higher budget R33 grant if milestones are met.
This research aims to develop targeted, effective treatments for botulism, which may be useful in generating therapies for other diseases of the nervous system.
Your link to the biggest stories in the suburbs delivered Thursday mornings.
Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter Get the Newsletter!
- FREE Elmbrook Memorial "Walk With A Wheaton Doc" – Saturday, April 26, 2014
- Children's Audition Notice for Milwaukee Rep's 2014/15 production THE COLOR PURPLE
- Stuff the Truck for Independence
- Spring Concert "Stars" featuring Julia Simpson
- Cudahy Home to be on Milwaukee/NARI Tour of Remodeled Homes
- Three Wauwatosa Homes to be Part of Annual Milwaukee/NARI Tour of Remodeled Homes
- United for Libraries to present Public Service Award to Congressman Jim Sensenbrenner (R-Wis.)
- MCW to Host Diabetes Symposium
- What statement will people REALLY be making on Denim Day, April 23?
- CYP Waukesha Hosts “Conservative Media Night” Networking Event