NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
46°
H 46° L 34°
Clear | 7MPH

Medical College Researcher to Study Vascular Anomalies

Feb. 25, 2012

Medical College Researcher to Study Vascular Anomalies

The Medical College of Wisconsin received a four-year, $1.5 million grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to investigate the underlying mechanism that generates errors in embryonic vascular development, which can lead to vascular anomalies.

Ramani Ramchandran, Ph.D., associate professor of pediatrics and cell biology, neurobiology and anatomy and director of the developmental vascular biology program at the Medical College, and an investigator at the Children’s Research Institute, is the principal investigator for the grant.

Vascular anomalies occur in one percent of the population. These abnormalities are malformations of the vascular system of capillaries, arteries and veins. Some cases involve relatively harmless birthmarks, but others can interfere with proper blood circulation and stress the heart to pump harder. These more serious cases often present a clinical challenge due to the lack of effective therapies available for treatment.

In this project, Dr. Ramchandran will study two genes, Sucrose non-fermenting related kinase-1 (Snrk-1) and Dual specific phosphatase-5 (Dusp-5), in which mutations were previously identified by his lab in patients with vascular anomalies. By understanding how these two genes influence the embryonic development of endothelial cells, which make up the interior lining of blood and lymphatic vessels, researchers hope to gain a better understanding of the formation of vascular anomalies.

Dr. Ramchandran’s research on these genes may provide viable new targets to combat these anomalies. It is further anticipated that FDA-approved drugs could be repurposed for vascular anomalies, which would greatly shorten the drug development cycle for these new targets.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Wauwatosa parents ask Sen. Leah Vukmir to increase education funding 4/27

» Wauwatosa parents to ask Sen. Vukmir to restore education funding at forum tonight 4/27

» Foreign officials take inspiration from Wauwatosa's Innovation Campus 4/23

» Wauwatosa fire chief addresses threat of oil tanker derailment 4/22

» Mount Mary students spruce up Wauwatosa businesses 4/22

» U-Haul moving into former Harley-Davidson plant in Wauwatosa 4/20

» Teen apparel store Garage coming to Mayfair 4/20

» Suburban Woman's Club of Wauwatosa awards scholarships to teachers 4/17

» Seniors now eligible for free Milwaukee County bus passes 4/16

» Irgens names Zywave as tenant for proposed office building in Wauwatosa 4/15

» Kmart closing in developing area of Wauwatosa 4/14

» Kmart in Wauwatosa will close 4/14

» UPDATE: Friday meeting will proceed without Rep. Kooyenga 4/14

» DOT resumes resurfacing work on Mayfair Road in Wauwatosa 4/13

» Diamond Stone headlines 2014-15 All-Suburban Boys Basketball team 4/13

» Wauwatosa now accepting electronic waste 4/9

» Tornado watch in effect 4/9

» Wauwatosa voters support Bradley, Cullen and state referendum 4/8

» Interactive: Test scores jump as Wauwatosa makes literacy a priority 4/8

» 2015 Milwaukee suburbs election roundup Updated:  4/8

» Eddie Cullen wins supervisor race to represent Wauwatosa 4/7

» Milwaukee man charged after fatal crash in Wauwatosa 4/6

» Popeye's proposed for Burleigh Street in Wauwatosa 4/3

» Wauwatosa teacher, student win Kohl Foundation awards 4/2

» Judge casts cloud over web of sex offender residency restrictions Updated:  4/1

View All Posts Got a tip? Welcome rss

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

2015 Writing Contest

 

(Click image for details)


Local Business Directory

CONNECT