NOW:53208:USA01012
http://widgets.journalinteractive.com/cache/JIResponseCacher.ashx?duration=5&url=http%3A%2F%2Fdata.wp.myweather.net%2FeWxII%2F%3Fdata%3D*USA01012
32°
H 32° L 27°
Cloudy | 5MPH

Medical College Researcher to Study Vascular Anomalies

Feb. 25, 2012

Medical College Researcher to Study Vascular Anomalies

The Medical College of Wisconsin received a four-year, $1.5 million grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to investigate the underlying mechanism that generates errors in embryonic vascular development, which can lead to vascular anomalies.

Ramani Ramchandran, Ph.D., associate professor of pediatrics and cell biology, neurobiology and anatomy and director of the developmental vascular biology program at the Medical College, and an investigator at the Children’s Research Institute, is the principal investigator for the grant.

Vascular anomalies occur in one percent of the population. These abnormalities are malformations of the vascular system of capillaries, arteries and veins. Some cases involve relatively harmless birthmarks, but others can interfere with proper blood circulation and stress the heart to pump harder. These more serious cases often present a clinical challenge due to the lack of effective therapies available for treatment.

In this project, Dr. Ramchandran will study two genes, Sucrose non-fermenting related kinase-1 (Snrk-1) and Dual specific phosphatase-5 (Dusp-5), in which mutations were previously identified by his lab in patients with vascular anomalies. By understanding how these two genes influence the embryonic development of endothelial cells, which make up the interior lining of blood and lymphatic vessels, researchers hope to gain a better understanding of the formation of vascular anomalies.

Dr. Ramchandran’s research on these genes may provide viable new targets to combat these anomalies. It is further anticipated that FDA-approved drugs could be repurposed for vascular anomalies, which would greatly shorten the drug development cycle for these new targets.

This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.

Suburban News Roundup

E-mail Newsletter

Your link to the biggest stories in the suburbs delivered Thursday mornings.


Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter
Get the Newsletter!

Login or Register to manage all your newsletter preferences.

Community Watch

» Westbound I-94 near Miller Park to close for 31 hours beginning Friday night 12/18

» Woman drives drunk to pick up drunken driver from police station 12/10

» Suspects of five related burglaries in Wauwatosa arrested, charged 12/9

» Woman threatens to stab Sak's employee after retail theft 12/9

» Wauwatosa aderman runs for Milwaukee County supervisor 12/8

» Anonymous email threatens Wauwatosa East High School 12/5

» 600 bowlers, volleyball players to compete at the Special Olympics Wisconsin on Saturday 12/4

» Kindergarten registration sessions announced 12/3

» Oconomowoc man, Eisenhower teacher, dies unexpectedly 11/29

» HomeGoods coming to Mayfair Collection 11/24

» Wauwatosa superintendent attends President Barack Obama's 'ConnectED to the Future' event 11/18

» Children's Hospital of Wisconsin moves babies to newly designed NICU 11/18

» City Market closes North Avenue location 11/17

» Early momentum doesn't stay with Tosa East 11/14

» Wauwatosa woman investigated for stealing credit card information from Froedtert Hospital patients 11/13

» Man pointed handgun at front door of Applebee's 11/10

» UW Credit Union branch could break ground in Wauwatosa this month 11/10

» Suburban roundup: Week three of the WIAA football postseason 11/10

» Indulgence Chocolatiers to open in Wauwatosa, and sell Purple Door Ice Cream 11/10

» Former Central States Mortgage CEO to plead guilty to obstruction of justice Updated:  11/6

» Tosa East stuns Brookfield East in volleyball sectional 11/6

» Election roundup: How the Milwaukee suburbs and Lake Country voted Updated:  11/5

» Walker wins Wauwatosa by slimmer margin than the state 11/5

» Walker's neighbors divided over election 11/4

» Authorities identify Wauwatosa man killed by train Updated:  11/4

View All Posts Got a tip? Welcome rss

Advertisement

Deal Watch - Milwaukee

Milwaukee's Best Discounts & Deals

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where reporter Rory Linnane explores the closed down and closed off parts of Wauwatosa.

Local Business Directory

CONNECT