PEOPLEBig splits! 2016 celebrity breakupsTopping the list of big celebrity breakups in 2016 are Brad Pitt and Angelina Jolie. After 12 years together, two as husband and wife, she filed for divorce in September. Click forward to see the big star couple splits this year.Mark J. Terrill, APAlmost a year after separating from Kate Beckinsale, director Len Wiseman filed for divorce in October. The couple has been married for 12 years and met on the set of 'Underworld.'Alberto E. Rodriguez, WireImageTobey Maguire and jewelry designer Jennifer Meyer announced their separation in October. They met in 2003 and have been married 9 years.Rachel Murray, Getty ImagesActor Liev Schreiber and Naomi Watts attended the 73rd Venice Film Festival in September just days before announcing their separation after 11 years together.Tiziana Fabi, AFP/Getty ImagesThose were the days. Angelina Jolie and Brad Pitt are still working out custody arrangements after she filed for divorce in September. The speculative headlines over this A-list star breakup are nonstop while their teams are reported to be negotiating behind closed doors.Matt Sayles, APIn July, a representative for Mary J Blige confirmed to USA TODAY that the singer filed for divorce from her husband of 12 years, Kendu Isaacs.Joel Ryan, APIn May, Amber Heard filed for divorce and asked for alimony, plus money from Johnny Depp for her attorney's fees. They had been married 15 months.Andrew Medichini, APAfter four years together, Garrett Hedlund, and Kirsten Dunst called it quits in late summer.Matt Sayles, Invision/APWilmer Valderrama, and Demi Lovato attended an Oscars party together in February, but in June, she announced their breakup.Evan Agostini, APIn June, NBA player Nick Young and Iggy Azalea announced their split a year after their engagement.Jacopo Raule, WireImageAfter nearly two years of dating, Josh Groban and Kat Dennings called it quits by late summer.Jason LaVeris, FilmMagicAfter dating for 15 months, Taylor Swift and Calvin Harris parted ways by June. And then, ...Kevin Mazur, WireImageSwift spent some time with Tom Hiddleston before reports soon surfaced that they, too, had broken up by summer's end. He told 'People' at the Emmys that he and the pop star are still friends ...Robyn Beck, AFP/Getty Images... Now the singer is lying low on the radar and appears to be single again.Suzanne Cordeiro, AFP/Getty ImagesOn-again, off-again couple Jennifer Lopez and Casper Smart were off again as of August.They had been linked since 2011.Gregg DeGuire, WireImageAfter five years together, Lady Gaga and Taylor Kinney broke up in July.Fred Hayes, Getty ImagesPeter Facinelli and Jaimie Alexander called off their engagement in February. They were engaged in March 2015.Dan MacMedan, USA TODAYAfter a year of dating, John Mellencamp and Christie Brinkley announced their split in August.Darron Cummings, APDrew Barrymore and Will Kopelman split in April after three years of marriage.Neilson Barnard, Getty ImagesAfter 10 years together, Joshua Jackson and Diane Kruger broke up mid-July. In August, 'People' asked how she was doing and she said, 'It's all good.'Evan Agostini, Invision/APDennis Quaid and wife Kimberly Buffington announced in June that they would be getting a divorce. The couple had announced splits twice previously during their 12-year marriage but always reconciled.Danny Moloshok, AP